Lab team

Buhrlage Lab for Cancer Chemical Biology

Welcome to the Buhrlage Lab

Our mission is to revolutionize our ability to interrogate deubiquitinase (DUB) biology, validate DUBs as therapeutic targets, and develop small molecule-based ligands suitable for clinical development. To accomplish this, we have established an integrated DUB-centric platform comprised of DUB-targeted libraries with novel scaffolds and chemotypes and a suite of established and novel biochemical and chemoproteomic assays to profile compound activity and selectivity, as well as expertise in DUB medicinal chemistry, structural biology, computational chemistry, and functional annotation.