Abhishek K. Singh, PhD

Dr. Singh Received his PhD from Jawaharlal Nehru University, India. During his doctoral training he studied redox mediated molecular regulation of leukemia cell proliferation/apoptosis and the functional aspect of inducible nitric oxide synthase in neutrophil differentiation and phagocytosis. In 2016, he joined the Cancelas Lab at the University of Cincinnati/CCHMC and carried research to understand the biology of bone marrow (BM) hematopoiesis during steady state and stress conditions. Dr. Singh’s research work has identified the previously unknown intercellular mitochondrial transport from transplanted hematopoietic stem and progenitors (HSPC) to the BM mesenchymal stromal cells (MSC) and provided a breakthrough in understanding towards the hematopoietic-dependent mesenchymal recovery, and consequent blood and bone regeneration. This specialized mitochondrial transfer is cell contact dependent and depends on the expression of the gap junction protein, Connexin 43 on the hematopoietic progenitors. Currently, he is studying the role of Connexin 43 in mitochondrial dynamics and fate with the goal to preserve HSC activity in ex vivo gene therapy approaches.
 

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