Cantley Lab Publications

Dr. Lewis Cantley Google Scholar

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• The intrinsic substrate specificity of the human tyrosine kinome. Yaron-Barir, T.M., Joughin, B.A., Huntsman, E.M. et al. Nature (2024). https://doi.org/10.1038/s41586-024-07407-y, www.nature.com/articles/s41586-024-07407-y

   

• Targeting chromosomal instability and downstream cytosolic dna signaling for cancer treatment
  LC Cantley, B Ngo, SF Bakhoum, US Patent App. 18/299,5582024, 2024

 

• Molecular Regulation of Transforming Growth Factor-β1-induced Thioredoxin-interacting Protein Ubiquitination and Proteasomal Degradation in Lung Fibroblasts: Implication in …
  SJ Taleb, Q Ye, B Baoyinna, M Dedad, D Pisini, NL Parinandi, LC Cantley, ...,Journal of respiratory biology and    translational medicine 1 (1)2024

 

• Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production
  EK Noch, L Palma, I Yim, N Bullen, D Barnett, A Walsh, B Bhinder, ...,Proceedings of the National Academy of Sciences 121 (8), e231734312122024

 

• Pan-cancer proteogenomics characterization of tumor immunity
  F Petralia, W Ma, TM Yaron, FP Caruso, N Tignor, JM Wang, ...,Cell52024

 

• Lineage-specific intolerance to oncogenic drivers restricts histological transformation
  EE Gardner, EM Earlie, K Li, J Thomas, MJ Hubisz, BD Stein, C Zhang, ...,Science 383 (6683), eadj1415, 2024

 

• NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis S Paul, SA Sarraf, KH Nam, L Zavar, N DeFoor, SR Biswas, LE Fritsch, ... Journal of Cell Biology 223 (2)2024

 

• Epinephrine inhibits PI3Kα via the Hippo kinases
  TY Lin, S Ramsamooj, T Perrier, K Liberatore, L Lantier, N Vasan, ...
  Cell Reports 42 (12)2023

 

• Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma
  EK Noch, LN Palma, I Yim, N Bullen, Y Qiu, H Ravichandran, J Kim, ...
  Neuro-oncology 25 (12), 2165-217612023

 

• Targeting chromosomal instability and downstream cytosolic DNA signaling for cancer treatment
  LC Cantley, B Ngo, SF Bakhoum, US Patent 11,821,0422023

 

• Deep learning integrates histopathology and proteogenomics at a pan-cancer level​
  JM Wang, R Hong, EG Demicco, J Tan, R Lazcano, AL Moreira, Y Li, ... Cell Reports Medicine 4 (9)2023

   

• Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
  WW Liang, RJH Lu, RG Jayasinghe, SM Foltz, E Porta-Pardo, Y Geffen, ...Cancer Cell 41 (9), 1567-1585. e722023

 

• Pan-cancer proteogenomics connects oncogenic drivers to functional states
  Y Li, E Porta-Pardo, C Tokheim, MH Bailey, TM Yaron, V Stathias, ...
  Cell 186 (18), 3921-3944. e2582023

 

• Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
  Y Geffen, S Anand, Y Akiyama, TM Yaron, Y Song, JL Johnson, ...
  Cell 186 (18), 3945-3967. e2662023

 

• Proteogenomic data and resources for pan-cancer analysis
  Y Li, Y Dou, FDV Leprevost, Y Geffen, AP Calinawan, F Aguet, Y Akiyama, ...
  Cancer Cell 41 (8), 1397-1406102023

 

• SARS-CoV-2 hijacks p38β/MAPK11 to promote virus replication
  CA Higgins, BE Nilsson-Payant, B Bonaventure, AP Kurland, C Ye, ...
  Mbio, e01007-2322023

 

• RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer
  A Jbara, KT Lin, C Stossel, Z Siegfried, H Shqerat, A Amar-Schwartz, ...
  Nature 617 (7959), 147-153192023

 

• Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader
  M Teng, J Jiang, ES Wang, Q Geng, ST Toenjes, KA Donovan, N Mageed, ...
  Angewandte Chemie 135 (18), e20230236412023

 

• The Hallmarks of a Cancer Discovery
  LA Diaz, LC Cantley
  Cancer Discovery 13 (4), 797-79822023

 

• An atlas of substrate specificities for the human serine/threonine kinome, Johnson, J.L., Yaron, T.M., Huntsman, E.M. et al. Nature 613, 759–766 (2023). https://doi.org/10.1038/s41586-022-05575-3, rdcu.be/dHklr​

   

• LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma
  BD Stein, JR Ferrarone, EE Gardner, JW Chang, D Wu, PE Hollstein, ..
  Cancer Discovery 13 (4), 1002-102522023

 

• Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity
  M Yoakim, W Hou, Z Songyang, Y Liu, L Cantley, B Schaffhausen
  Molecular and cellular biology432023

 

• ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor
  TP Soltoff, KL Carraway III, SA Prigent, WG Gullick, LC Cantley
  Molecular and cellular biology