Chouchani Lab Research Highlights

Lactate regulates cell cycle by remodelling the anaphase promoting complex

Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor

Architecture of the outbred brown fat proteome defines regulators of metabolic physiology

Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation​

UCP1 governs liver extracellular succinate and inflammatory pathogenesis​

pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity

Accumulation of succinate controls activation of adipose tissue thermogenesis

A Unifying Mechanism for Mitochondrial Superoxide ​Production during Ischemia-Reperfusion Injury