Collins Genomics Lab
Welcome to the CGL!
We are a group of collaborative cancer researchers at Dana-Farber Cancer Institute who are mining the human genome to answer three questions:
1. Predisposition: who is most likely to get cancer—especially early-onset disease—due to genetics?
2. Tumorigenesis: how does the DNA in each healthy cell encode resilience or susceptibility to becoming a cancer cell?
3. Early intervention: what is the role of genomics in anticipating & intercepting cancer as early as possible?
CGL Research Highlights
Gillani & Collins et al., Science (2025) | By comparing the genomes of children with cancer to cancer-free adults, we discovered new explanations for these childhood malignancies.
Collins et al., Cell (2022) | We spearheaded an international federation of hospitals, commercial laboratories, and national biobanks to compare one million genomes across 54 diseases.
Collins & Brand et al., Nature (2020) | We led one arm of the initial version of the Genome Aggregation Database (gnomAD), the world's largest reference for human genetic variation.
Curious to learn more?
Read about our current research topics, meet the members of our team, learn about our lab's values, or review a list of our publications.
Want to get involved?
• For scientists: we are always looking for new members to join our team! See our latest opportunities.
• For generous individuals: your tax-deductible donations can fuel our cutting-edge research. Support CGL.
