Filbin Lab Publications

2024 Publications

GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant

Ilon Liu, Gustavo Alencastro Veiga Cruzeiro, Lynn Bjerke, Rebecca F Rogers, Yura Grabovska, Alexander Beck, Alan Mackay, Tara Barron...Johannes Gojo, Michelle Monje, Chris Jones, Mariella G Filbin

CANCER CELL - 2024
DOI: 10.1016/j.ccell.2024.08.006

Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology

Gödicke, S., Kresbach, C., Ehlert, M., Obrecht, D., Altendorf, L., Hack, K., von Hoff, K., Carén, H., Melcher, V., Kerl, K., Englinger, B., Filbin, M., Pajtler, K. W., Gojo, J., Pietsch, T., Rutkowski, S., & Schüller, U.

ACTA NEUROPATHOLOGICA - 2024
https://doi.org/10.1007/s00401-023-02682-x

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma

Casillo, S. M., Gatesman, T. A., Chilukuri, A., Varadharajan, S., Johnson, B. J., David Premkumar, D. R., Jane, E. P., Plute, T. J., Koncar, R. F., Stanton, A. J., Biagi-Junior, C. A. O., Barber, C. S., Halbert, M. E., Golbourn, B. J., Halligan, K., Cruz, A. F., Mansi, N. M., Cheney, A., Mullett, S. J., Land, C. V., … Filbin, M. G., ... Agnihotri, S.

CELL REPORTS - 2024
https://doi.org/10.1016/j.celrep.2023.113557

A road map for the treatment of pediatric diffuse midline glioma

Koschmann, C., Al-Holou, W. N., Alonso, M. M., Anastas, J., Bandopadhayay, P., Barron, T., Becher, O., Cartaxo, R., Castro, M. G., Chung, C., Clausen, M., Dang, D., Doherty, R., Duchatel, R., Dun, M., Filbin, M., Franson, A., Galban, S., Garcia Moure, M., Garton, H., … Venneti, S.

CANCER CELL - 2024
https://doi.org/10.1016/j.ccell.2023.11.002

2023 Publications

TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory 4

Ausejo-Mauleon, I., Labiano, S., de la Nava, D., Laspidea, V., Zalacain, M., Marrodán, L., García-Moure, M., González-Huarriz, M., Hervás-Corpión, I., Dhandapani, L., Vicent, S., Collantes, M., Peñuelas, I., Becher, O. J., Filbin, M. G., Jiang, L., Labelle, J., de Biagi-Junior, C. A. O., Nazarian, J., Laternser, S., … Alonso, M. M.

CANCER CELL - 2023
https://doi.org/10.1016/j.ccell.2023.09.001

Diffuse Midline Glioma Invasion and Metastasis Rely on Cell-autonomous Signaling

Bruschi, M., Midjek, L., Ajlil, Y., Vairy, S., Lancien, M., Ghermaoui, S., Kergrohen, T., Verreault, M., Idbaih, A., de Biagi, C. A. O., Jr, Liu, I., Filbin, M. G., Beccaria, K., Blauwblomme, T., Puget, S., Tauziede-Espariat, A., Varlet, P., Dangouloff-Ros, V., Boddaert, N., Le Teuff, G., … Castel, D.

NEURO-ONCOLOGY - 2023
https://doi.org/10.1093/neuonc/noad161

A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4

Williams, E. A., Brastianos, P. K., Wakimoto, H., Zolal, A., Filbin, M. G., Cahill, D. P., Santagata, S., & Juratli, T. A.

ACTA NEUROPATHOLOGICA - 2023
https://doi.org/10.1007/s00401-023-02609-6

Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways

Venneti, S., Kawakibi, A. R., Ji, S., Waszak, S. M., Sweha, S. R., Mota, M., Pun, M., Deogharkar, A., Chung, C., Tarapore, R. S., Ramage, S., Chi, A., Wen, P. Y., Arrillaga-Romany, I., Batchelor, T. T., Butowski, N. A., Sumrall, A., Shonka, N., Harrison, R. A., de Groot, J., … Filbin, M. G., ... Koschmann, C.

CANCER DISCOVERY - 2023
https://doi.org/10.1158/2159-8290.CD-23-0131

Mapping pediatric brain tumors to their origins in the developing cerebellum

Okonechnikov, K., Joshi, P., Sepp, M., Leiss, K., Sarropoulos, I., Murat, F., Sill, M., Beck, P., Chan, K. C., Korshunov, A., Sahm, F., Deng, M. Y., Sturm, D., DeSisto, J., Donson, A. M., Foreman, N. K., Green, A. L., Robinson, G., Orr, B. A., Gao, Q., … Filbin, M. G., ... Pfister, S. M.

NEURO-ONCOLOGY - 2023
https://doi.org/10.1093/neuonc/noad124

Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances

Hwang, E. I., Hanson, D., Filbin, M. G., & Mack, S. C.

NEUOPLASIA - 2023
https://doi.org/10.1016/j.neo.2023.100895

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

Pun, M., Pratt, D., Nano, P. R., Joshi, P. K., Jiang, L., Englinger, B., Rao, A., Cieslik, M., Chinnaiyan, A. M., Aldape, K., Pfister, S., Filbin, M. G., Bhaduri, A., & Venneti, S.

ACTA NEUROPATHOLOGICA COMMUNICATIONS - 2023
https://doi.org/10.1186/s40478-023-01514-z

Neuronal-Activity dependent mechanismas of small cell lung cancer progression

Savchuk, S., Gentry, K., Wang, W., Carleton, E., Yalçın, B., Liu, Y., Pavarino, E. C., LaBelle, J., Toland, A. M., Woo, P. J., Qu, F., Filbin, M. G., Krasnow, M. A., Sabatini, B. L., Sage, J., Monje, M., & Venkatesh, H. S.

BIORXIV - 2023
https://doi.org/10.1101/2023.01.19.524430

2022 Publications

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Liu, I., Jiang, L., Samuelsson, E. R., Marco Salas, S., Beck, A., Hack, O. A., Jeong, D., Shaw, M. L., Englinger, B., LaBelle, J., Mire, H. M., Madlener, S., Mayr, L., Quezada, M. A., Trissal, M., Panditharatna, E., Ernst, K. J., Vogelzang, J., Gatesman, T. A., Halbert, M. E., … Filbin, M. G.

NATURE GENETICS - 2022
https://doi.org/10.1038/s41588-022-01236-3

Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods

2023-neuro-oncology

Gonzalez Castro, L. N., Liu, I., & Filbin, M.

NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac211

BAF complex maintains glioma stem cells in pediatric H3K27M-glioma

Panditharatna, E., G Marques, J., Wang, T., Trissal, M. C., Liu, I., Jiang, L., Beck, A., Groves, A., Dharia, N. V., Li, D., Hoffman, S. E., Kugener, G., Shaw, M. L., Mire, H. M., Hack, O. A., Dempster, J. M., Lareau, C., Dai, L., Sigua, L. H., Quezada, M. A., … Filbin, M. G. 

cancer-discovery-baf-article_3

CANCER DISCOVERY - 2022
https://doi.org/10.1158/2159-8290.CD-21-1491

VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system

So, J., Mabe, N. W., Englinger, B., Chow, K. H., Moyer, S. M., Yerrum, S., Trissal, M. C., Marques, J. G., Kwon, J. J., Shim, B., Pal, S., Panditharatna, E., Quinn, T., Schaefer, D. A., Jeong, D., Mayhew, D. L., Hwang, J., Beroukhim, R., Ligon, K. L., Stegmaier, K., … Filbin G. M., Hahn, W. C.

JCI INSIGHT - 2022
https://doi.org/10.1172/jci.insight.158755

Immunotherapy approaches for the treatment of diffuse midline gliomas

Bernstock, J. D., Hoffman, S. E., Kappel, A. D., Valdes, P. A., Essayed, W., Klinger, N. V., Kang, K. D., Totsch, S. K., Olsen, H. E., Schlappi, C. W., Filipski, K., Gessler, F. A., Baird, L., Filbin, M. G., Hashizume, R., Becher, O. J., & Friedman, G. K.

ONCOIMMUNOLOGY - 2022
https://doi.org/10.1080/2162402X.2022.2124058

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

Pal, S., Kaplan, J. P., Nguyen, H., Stopka, S. A., Savani, M. R., Regan, M. S., Nguyen, Q. D., Jones, K. L., Moreau, L. A., Peng, J., Dipiazza, M. G., Perciaccante, A. J., Zhu, X., Hunsel, B. R., Liu, K. X., Alexandrescu, S., Drissi, R., Filbin, M. G., McBrayer, S. K., Agar, N. Y. R., … Haas-Kogan, D. A.

CANCER CELL - 2022
https://doi.org/10.1016/j.ccell.2022.07.012

An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin

Zats, L. P., Ahmad, L., Casden, N., Lee, M. J., Belzer, V., Adato, O., Bar Cohen, S., Ko, S. B., Filbin, M. G., Unger, R., Lauffenburger, D. A., Segal, R. A., & Behar, O.

NEURO-ONCOLOGY ADVANCES - 2022
https://doi.org/10.1093/noajnl/vdac117

Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

Harpaz, N., Mittelman, T., Beresh, O., Griess, O., Furth, N., Salame, T. M., Oren, R., Fellus-Alyagor, L., Harmelin, A., Alexandrescu, S., Marques, J. G., Filbin, M. G., Ron, G., & Shema, E.

MOLECULAR CELL - 2022
https://doi.org/10.1016/j.molcel.2022.05.023

Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in Supratentorial Ependymoma

de Almeida Magalhães, T., Alencastro Veiga Cruzeiro, G., Ribeiro de Sousa, G., Englinger, B., Fernando Peinado Nagano, L., Ancliffe, M., Rodrigues da Silva, K., Jiang, L., Gojo, J., Cherry Liu, Y., Carline, B., Kuchibhotla, M., Pinto Saggioro, F., Kazue Nagahashi Marie, S., Mieko Oba-Shinjo, S., Andres Yunes, J., Gomes de Paula Queiroz, R., Alberto Scrideli, C., Endersby, R., Filbin, M. G., … Valera, E. T.

NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac147

Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma

Messinger, D., Harris, M. K., Cummings, J. R., Thomas, C., Yang, T., Sweha, S. R., Woo, R., Siddaway, R., Burkert, M., Stallard, S., Qin, T., Mullan, B., Siada, R., Ravindran, R., Niculcea, M., Dowling, A. R., Bradin, J., Ginn, K. F., Gener, M. A. H., Dorris, K., … Filbin, M. G., ... Yadav, V. N.

NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac141

Bromodomain and Extra-Terminal Protein Inhibitors: Biologic Insights and Therapeutic Potential in Pediatric Brain Tumors

Groves, A., Clymer, J., & Filbin, M. G.

PHARMACEUTICALS (BASEL, SWITZERLAND) - 2022
https://doi.org/10.3390/ph15060665

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

Majzner, R. G., Ramakrishna, S., Yeom, K. W., Patel, S., Chinnasamy, H., Schultz, L. M., Richards, R. M., Jiang, L., Barsan, V., Mancusi, R., Geraghty, A. C., Good, Z., Mochizuki, A. Y., Gillespie, S. M., Toland, A. M. S., Mahdi, J., Reschke, A., Nie, E. H., Chau, I. J., Rotiroti, M. C., … Filbin, M. G., ... Monje, M.

NATURE - 2022
https://doi.org/10.1038/s41586-022-04489-4

Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas

Przystal, J. M., Cianciolo Cosentino, C., Yadavilli, S., Zhang, J., Laternser, S., Bonner, E. R., Prasad, R., Dawood, A. A., Lobeto, N., Chin Chong, W., Biery, M. C., Myers, C., Olson, J. M., Panditharatna, E., Kritzer, B., Mourabit, S., Vitanza, N. A., Filbin, M. G., de Iuliis, G. N., Dun, M. D., … Nazarian, J.

NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac041

2021 Publications

The imitation game: How glioblastoma outmaneuvers immune attack

Liu, I., Hack, O. A., & Filbin, M. G.

CELL - 2021
https://doi.org/10.1016/j.cell.2021.04.008

Understanding the epigenetic landscape and cellular architecture of childhood brain tumors

Alencastro Veiga Cruzeiro, G., Rota, C., Hack, O. A., Segal, R., & Filbin, M. G.

NEUROCHEMISTRY INTERNATIONAL - 2021
https://doi.org/10.1016/j.neuint.2020.104940

Outcomes after first relapse of childhood intracranial ependymoma

Tsai, J. W., Manoharan, N., Alexandrescu, S., Zimmerman, M. A., Scully, J., Chordas, C., Clymer, J., Wright, K. D., Filbin, M., Ullrich, N. J., Marcus, K. J., Haas-Kogan, D., Chi, S. N., Bandopadhayay, P., & Yeo, K. K.

PEDIATRIC BLOOD & CANCER - 2021
https://doi.org/10.1002/pbc.28930

Targeting fibroblast growth factor receptors to combat aggressive ependymoma.

Lötsch, D., Kirchhofer, D., Englinger, B., Jiang, L., Okonechnikov, K., Senfter, D., Laemmerer, A., Gabler, L., Pirker, C., Donson, A. M., Bannauer, P., Korbel, P., Jaunecker, C. N., Hübner, J. M., Mayr, L., Madlener, S., Schmook, M. T., Ricken, G., Maaß, K., Grusch, M., … Filbin, M. G., ... Gojo, J.

ACTA NEUROPATHOLOGICA- 2021
https://doi.org/10.1007/s00401-021-02327-x

Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

Panwalkar, P., Tamrazi, B., Dang, D., Chung, C., Sweha, S., Natarajan, S. K., Pun, M., Bayliss, J., Ogrodzinski, M. P., Pratt, D., Mullan, B., Hawes, D., Yang, F., Lu, C., Sabari, B. R., Achreja, A., Heon, J., Animasahun, O., Cieslik, M., Dunham, C., … Filbin, M. G., ... Venneti, S.

SCIENCE TRANSLATIONAL MEDICINE - 2021
https://doi.org/10.1126/scitranslmed.abc0497

2020 Publications

Into Thin Air: Hypoxia drives metabolic and epigenomic deregulation of lethal pediatric ependymoma

Englinger, B., Hack, O. A., & Filbin, M. G.

DEVELOPMENTAL CELL - 2020
https://doi.org/10.1016/j.devcel.2020.06.020

Molecular and clinicopathologic features of gliomas harboring NTRK fusions

Torre, M., Vasudevaraja, V., Serrano, J., DeLorenzo, M., Malinowski, S., Blandin, A. F., Pages, M., Ligon, A. H., Dong, F., Meredith, D. M., Nasrallah, M. P., Horbinski, C., Dahiya, S., Ligon, K. L., Santi, M., Ramkissoon, S. H., Filbin, M. G., Snuderl, M., & Alexandrescu, S.

ACTA NEUROPATHOLOGICA COMMUNICATIONS - 2020
https://doi.org/10.1186/s40478-020-00980-z

Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma

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Gojo J, Englinger B, Jiang L, Hübner JM, Shaw ML, Hack OA, Madlener S, Kirchhofer D, Liu I, Pyrdol J, Hovestadt V, Mazzola E, Mathewson ND, Trissal M, Lötsch D, Dorfer C, Haberler C, Halfmann A, Mayr L, Peyrl A, Geyeregger R, Schwalm B, Mauermann M, Pajtler KW, Milde T, Shore ME, Geduldig JE, Pelton K, Czech T, Ashenberg O, Wucherpfennig KW, Rozenblatt-Rosen O, Alexandrescu S, Ligon KL, Pfister SM, Regev A, Slavc I, Berger W, Suvà ML, Kool M, Filbin MG.

CANCER CELL - 2020
https://doi.org/10.1016/j.ccell.2020.06.004

The growing role of epigenetics in childhood cancers

Panditharatna, E., & Filbin, M. G.

CURRENT OPINION IN PEDIATRICS - 2020
https://doi.org/10.1097/MOP.0000000000000867

Molecular and Clinicopathologic Features of Gliomas Harboring NTRK Fusions

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

Chen, C. C. L., Deshmukh, S., Jessa, S., Hadjadj, D., Lisi, V., Andrade, A. F., Faury, D., Jawhar, W., Dali, R., Suzuki, H., Pathania, M., A, D., Dubois, F., Woodward, E., Hébert, S., Coutelier, M., Karamchandani, J., Albrecht, S., Brandner, S., De Jay, N., … Filbin, M. G., ... Jabado, N.

CELL - 2020
https://doi.org/10.1016/j.cell.2020.11.012

Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma.

Manoharan N, Choi J, Chordas C, Zimmerman MA, Scully J, Clymer J, Filbin M, Ullrich NJ, Bandopadhayay P, Chi SN, Yeo KK.

J. NEURONCOL, 2020;149(2):253-262. https://doi.org/10.1007/s11060-020-03592-8

Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas.

Dorfer C, Czech T, Gojo J, Hosmann A, Peyrl A, Azizi AA, Kasprian G, Dieckmann K, Filbin MG, HaberlerG, Roessler K, Slavc I.

ACTA NEUROCHIR (WIEN), 2020; 163(7):2025-2035. https://doi.org/10.1007/s00701-020-04589-y

2019 Publications

Increasing value of autopsies in patients with brain tumors in the molecular era.

Ahrendsen JT, Filbin MG, Chi SN, Manley PE, Wright KD, Bandopadhayay P, Clymer JR, Yeo KK, Kieran MW, Jones R, Lidov HG, Ligon KL, Alexandrescu S.

J NEUROONCOL, 2019; 145:349–355. https://doi.org/10.1007/s11060-019-03302-z

Histone variant and cell context determine H3K27M reprogramming of the enhancer landscape and oncogenic state.

Nagaraja S, Quezada MA, Gillespie SM, Arzt M, Lennon JJ, Woo PJ, Hovestadt V, Kambhampati M, Filbin MG, Suva ML, Nazarian J, Monje M.

MOL CELL, 2019; S1097-2765(19):30685-9. https://doi.org/10.1016/j.molcel.2019.08.030

Rapid generation of somatic mouse mosaics with locus-specific, stably integrated transgenic elements.

Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ.

CELL, 2019; 179(1):251-267.e24. https://doi.org/10.1016/j.cell.2019.08.013

Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG.

Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen Q-D, Suvà ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG*, Shi Y*.
* contributed equally and co-corresponding

CANCER CELL, 2019; in press. https://doi.org/10.1016/j.ccell.2019.09.005

Resolving medulloblastoma cellular architecture by single-cell genomics.

Hovestadt V*, Smith KS*, Bihannic L*, Filbin MG*, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA.
* contributed equally

NATURE, 2019; 572(7767):74-79. https://doi.org/10.1038/s41586-019-1434-6

An integrative model of cellular states, plasticity, and genetics for glioblastoma.

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Neftel C*, Laffy J*, Filbin MG*, Hara T*, Shore ME, Rahme GJ, Richman AR, Silverbush D, Shaw ML, Hebert CM, Dewitt J, Gritsch S, Perez EM, Gonzalez Castro LN, Lan X, Druck N, Rodman C, Dionne D, Kaplan A, Bertalan MS, Small J, Pelton K, Becker S, Bonal D, Nguyen QD, Servis RL, Fung JM, Mylvaganam R, Mayr L, Gojo J, Haberler C, Geyeregger R, Czech T, Slavc I, Nahed BV, Curry WT, Carter BS, Wakimoto H, Brastianos PK, Batchelor TT, Stemmer-Rachamimov A, Martinez-Lage M, Frosch MP, Stamenkovic I, Riggi N, Rheinbay E, Monje M, Rozenblatt-Rosen O, Cahill DP, Patel AP, Hunter T, Verma IM, Ligon KL, Louis DN, Regev A, Bernstein BE, Tirosh I, Suvà ML.
* contributed equally

CELL, 2019; 178(4):835-849.e21. https://doi.org/10.1016/j.cell.2019.06.024

Developmental origins and emerging therapeutic opportunities for childhood cancer.

Filbin M, Monje M.

NATURE MEDICINE, 2019; 25(3):367-376. https://doi.org/10.1038/s41591-019-0383-9

2013 - 2018 Publications

Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma.

Lin GL, Nagaraja S, Filbin MG, Suva ML, Vogel H, Monje M

ACTA NEUROPATHOL COMMUN, 2018; 6:51. https://doi.org/10.1186/s40478-018-0553-x

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.

Filbin MG*, Tirosh I*, Hovestadt V*, Shaw ML, Escalante LE, Mathewson ND, Neftel C, Frank N, Pelton K, Hebert CM, Haberler C, Yizhak K, Gojo J, Egervari K, Mount C, Van Galen P, Bonal D, Nguyen QD, Beck A, Sinai C, Czech T, Dorfer C, Goumnerova L, Lavarino C, Carcaboso AM, Mora J, Mylvaganam R, Luo CC, Peyrl A, Popovic M, Azizi A, Batchelor TT, Frosch MP, Martinez-Lage M, Kieran MW, Bandopadhayay P, Beroukhim R, Fritsch G, Getz G, Rozenblatt-Rosen O, Wucherpfennig KW, Louis DN, Monje M, Slavc I, Ligon KL, Golub TR, Regev A, Bernstein B, Suva ML.
* contributed equally

SCIENCE, 2018; 360:331-335. https://doi.org/10.1126/science.aao4750

Gliomas in Children.

Filbin MG, Sturm D.

SEMINARS IN NEUROLOGY, 2018; 38:121-130. https://doi.org/10.1055/s-0038-1635106

Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas.

Juratli TA, Qin N, Cahill DP, Filbin MG.

PHARMACOL THER, 2018; 182:70-79. https://doi.org/10.1016/j.pharmthera.2017.08.006

Decoupling genetic developmental and micro-environmental programs in IDH-mutant gliomas thorugh single-cell RNA-seq.

Venteicher AS, Tirosh I, Hebert C, Yizhak K, Neftel C, Filbin MG, Hovestadt V, Escalante LE, Shaw ML, Rodman C, Gillespie SM, Dionne D, Luo CC, Ravichadran H, Mylvaganam R, Mout C, Onozato ML, Nahed BV, Wakimoto H, Curry WT, Iafrate AJ, Rivera MN, Frosch MP, Golub TR, Brastianos PK, Getz G, Patel AP, Monje J, Cahill DP, Rozenblatt-Rosen O, Louis DN, Bernstein BE, Regev A, Suva ML.

SCIENCE, 2017; 355(6332). https://doi.org/10.1126/science.aai8478

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

Ramkissoon SH, Bandopadhayay P, Hwang J, Ramkissoon LA, Greenwald NF, Schumacher SE, O'Rourke R1, Pinches N, Ho P, Malkin H, Sinai C, Filbin M, Plant A, Bi WL, Chang MS, Yang E, Wright KD, Manley PE, Ducar M, Alexandrescu S, Lidov H, Delalle I, Goumnerova LC, Church AJ, Janeway KA, Harris MH, MacConaill LE, Folkerth RD, Lindeman NI, Stiles CD, Kieran MW, Ligon AH, Santagata S, Dubuc AM, Chi SN, Beroukhim R, Ligon KL.

NEURO ONCOL, 2017; 7:986-996. https://doi.org/10.1093/neuonc/now294

Single cell RNA-seq supports a developmental hierarchy in IDH-mutant oligodendroglioma.

Tirosh I, Venteicher AS, Hebert C, Escalante LE, Patel AP, Yizhak K, Fisher JM, Rodman C, Mount C, Filbin MG, Neftel C, Desai N, Nyman J, Izar B, Luo CC, Francis JM, Patel AA, Onozato, Riggi N, Livak KJ, Gennert D, Satija R, Nahed BV, Curry WT, Martuza RL, Mylvaganam R, Iafrate AJ, Frosch MP, Golub T, Rivera MN, Getz G, Rozenblatt-Rosen O, Cahill D, Monje M, Bernstein BE, Louis DN, Regev A, Suva ML.

NATURE, 2016; 539(7628):309-313. https://doi.org/10.1038/nature20123

Glioma genomics and epigenomics: arriving at the start and knowing it for the first time.

Filbin MG, Suva ML.

ANNU REV PATHOL, 2016; 11:497-521. https://doi.org/10.1146/annurev-pathol-012615-044208

Of Brains and Blood: Developmental Origins of Glioma Diversity?

Filbin MG, Stiles CD.

CANCER CELL, 2015; 28(3):403-404. https://doi.org/10.1016/j.ccell.2015.09.013

How neuronal activity regulates glioma cell proliferation.

Filbin MG, Segal RA.

NEURO ONCOL, 2015; 17(12): 1543-1544. https://doi.org/10.1093/neuonc/nov188

A brain tumor/organotypic slice co-culture system for studying tumor microenvironment and targeted drug therapies.

Chadwick, E. J., Yang, D. P., Filbin, M. G., Mazzola, E., Sun, Y., Behar, O., Pazyra-Murphy, M. F., Goumnerova, L., Ligon, K. L., Stiles, C. D., & Segal, R. A.

J VIS EXP, 2015; https://doi.org/10.3791/53304

Coordinate activation of Shh and PI3K signaling in PTEN-deficient Glioblastoma: new therapeutic opportunities.

Filbin, M. G., Dabral, S. K., Pazyra-Murphy, M. F., Ramkissoon, S., Kung, A. L., Pak, E., Chung, J., Theisen, M. A., Sun, Y., Franchetti, Y., Sun, Y., Shulman, D. S., Redjal, N., Tabak, B., Beroukhim, R., Wang, Q., Zhao, J., Dorsch, M., Buonamici, S., Ligon, K. L., … Segal, R. A.

NATURE MEDICINE, 2013; https://doi.org/10.1038/nm.3328