Welcome to the Fischer Lab

The Ubiquitin Proteasome System is involved in virtually any cellular process and frequently implicated in human diseases. The Fischer lab combines structural biology, cell biology, and high throughput biology approaches to understand the mechanistic principles that govern signaling through the ubiquitin proteasome system. We leverage these insights to propose and test new avenues of therapeutic intervention, such as targeted protein degradation or SPLiNTs. Our work has contributed to the now widespread application of targeted protein degradation in drug development and as a powerful tool to study biology.
 
We cultivate a multi-disciplinary and highly collaborative approach to science to tackle fundamental questions in biology and pharmacology. We also work closely with the Center for Protein Degradation at Dana-Farber Cancer Institute on the development of novel therapeutics.

The Fischer Lab is part of:
Department of Cancer Biology - Dana-Farber Cancer Institute
Department of Biological Chemistry & Molecular Pharmacology (BCMP) - Harvard Medical School
The Chemical Biology Program - Dana-Farber Cancer Institute 
The Center for Protein Degradation - Dana-Farber Cancer Institute