Mancias Lab
Pancreatic Cancer Research
Welcome to the Mancias Lab
The Mancias Lab, located at the Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, in Boston, Massachusetts, is focused on the study of pancreatic cancer. Pancreatic cancer is a highly lethal and treatment refractory cancer with patients succumbing to the disease on average within 6 months of diagnosis. As the third leading cause of cancer death in the United States, pancreatic cancer patients are in desperate need of new treatment approaches. The Mancias Lab studies critical aspects of the biology of pancreatic cancer in order to develop novel therapeutic approaches. The lab takes a comprehensive approach combining biochemical, quantitative mass spectrometry-based proteomic, gene editing, cell biological, and mouse modeling techniques to advance our understanding of pancreatic cancer.
Pancreatic Cancer Research News from the Mancias Lab
Our study was published today in Cancer Discovery! The study is entitled "NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins".
We are excited to welcome Shin to the lab as a joint Postdoctoral Fellow with the Gygi Lab (Harvard Medical School). Shin joins the lab after a successful PhD in the lab of Professor Ku-Lung Hsu at the University of Virginia, Department of Chemistry.
Welcome to the lab, Dr. Thuy Nguyen! Thuy joins the lab after a successful graduate school experience in the lab of Professor Tae-Il Jeon at the Chonnam National University in South Korea. There, Thuy discovered a novel mechanism of sterol regulator element binding protein - 1c (SREBP-1c) in autophagy flux, contributing to hepatic steatosis in high-fat diet mice.
Welcome (back) to the lab, Matt! Matt was previously in the lab as a Boston University Master's student and successfully completed a thesis in the lab. He now joins the lab as a Research Technician who will help with multiple projects related to pancreatic cancer biology while preparing for medical school applications.
We are excited for Claudia to join the lab. Claudia just graduated from Tennessee Wesleyan University with Honors while majoring in Biology. During her undergraduate time she worked in multiple labs, including at the Oak Ridge National Laboratory.
We celebrated Dr. Naiara Santana-Codina's time in the lab at TimeOut Market! Naiara was one of the first members of the lab and has had an amazingly productive time in the lab with three first author research articles (in Cancer Discovery, Nature, Haematologica, Cell Reports) and multiple first author reviews (including in Annual Reviews of Cancer Biology).
Our latest publication is now online at Cancer Discovery!
