Primary Articles

Primary articles are original research publications where a member of the Meyerson laboratory is either first, co-first, corresponding, co-corresponding, senior, or co-senior author.

2026

Dohlman A, ..., Meyerson M. (2026) Biodiversity and biogeography of the multi-kingdom cancer microbiome. Cell. https://doi.org/10.1016/j.cell.2026.04.015
Ma K, ..., Meyerson M, & ... (2026). ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging. Cell. https://doi.org/10.1016/j.cell.2026.04.010
Aquilanti, EA, ... & Meyerson, M. (2026). Rapid loss of viability in acute myeloid leukemia cells upon telomerase inactivation. Blood Advances. https://doi.org/10.1182/bloodadvances.2025018090

2025

Siegel F, ... Meyerson M & Greulich H. (2025) Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer. Cancer Discovery https://doi.org/10.1158/2159-8290.cd-25-0605
Sadagopan, A, ... Meyerson, M & Gibson, WJ. (2025). Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs. Nature Chemical Biology. https://doi.org/10.1038/s41589-025-02051-7
Lee, IT, ... Meyerson, M & Makinen, N. (2025). Chraracterization of tumor-associated microbiome in multifocal small intestinal neuroendocrine tumors (SI-NETs). ESMO Gastrointestinal Oncology. https://doi.org/10.1016/j.esmogo.2025.100229
Ahmad, S, Zou, T, … Meyerson, M, & ... (2025). PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration. Nature Communications. https://www.nature.com/articles/s41467-025-58433-x
Pulice, JL, & Meyerson, M (2025). Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma. Molecular Cell. https://www.cell.com/molecular-cell/abstract/S1097-2765(25)00194-7
Aquilanti, E, … & Meyerson, M (2025). High-Throughput Screening Tool to Identify Small Molecule Inhibitors of Telomerase. ACS Chemical Biology. https://doi.org/10.1021/acschembio.5c00244
Ellrott, K, ... Cherniack, AD, & … (2025). Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets. Cancer Cell. https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00477-X

2024

Hayes, TK, … & Meyerson, M (2024). Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature Communications. https://www.nature.com/articles/s41467-024-45594-4
Zou, T, ... & Meyerson, M (2024). XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells. Cell Reports. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01612-1?uuid=uuid%3Af0ac5628-6b6b-49ed-88f8-eedcbf76f39d
Tan, KT, … & Meyerson, M (2024). Neotelomeres and telomere-spanning chromosomal arm fusions in cancer genomes revealed by long-read sequencing. Cell Genomics. https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00172-1?uuid=uuid%3A99deb3cd-ab67-4337-9a72-fc6217aee446
Yermalovich, AV, … & Meyerson, M (2024). An essential role for Cmtr2 in mammalian embryonic development. Developmental Biology. https://www.sciencedirect.com/science/article/pii/S0012160624001994
Aquilanti, E, … Meyerson, M, & Greulich, H (2024). Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression. Neuro-oncology Advances. https://academic.oup.com/noa/article/6/1/vdae115/7701986

2023

Tarantino, P, Gupta, H, Hughes, ME, Files, J, & ... (2023). Comprehensive genomic characterization of HER2-low and HER2-0 breast cancer. Nature Communications. https://www.nature.com/articles/s41467-023-43324-w
Gibson, WJ, … Meyerson, M & ... (2023). Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.3c06179
Aquilanti, E, … & Meyerson, M (2023). Telomerase inhibition is an effective therapeutic strategy in TERT promoter-mutant glioblastoma models with low tumor volume. Neuro-Oncology. https://academic.oup.com/neuro-oncology/article-abstract/25/7/1275/7000407
Shih, J, & ... (2023). Cancer aneuploidies are shaped primarily by effects on tumour fitness. Nature. https://www.nature.com/articles/s41586-023-06266-3
Orsi, DL, … Meyerson, M, … & Goldstein, JT (2023). Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as a covalent PPARG inverse-agonists. Bioorganic & Medicinal Chemistry. https://doi.org/10.1016/j.bmc.2022.117130

2022

Zhang, Z, Golomb, L, & Meyerson, M (2022). Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell Lines. Cancer Research. https://aacrjournals.org/cancerres/article-abstract/82/11/2171/699103
Mäkinen, N, … & Meyerson, M (2022). Whole genome sequencing reveals the independent clonal origin of multifocal ileal neuroendocrine tumors. Genome Medicine. https://doi.org/10.1186/s13073-022-01083-1
Zhou, M, … Meyerson, M, Viswanathan, SR, & Ha, G (2022). Patterns of structural variation define prostate cancer across disease states. JCI Insights. https://pmc.ncbi.nlm.nih.gov/articles/PMC9536266/
Tan, KT, Slevin, MK, Meyerson, M, & Li, H (2022). Identifying and correcting repeat-calling errors in nanopore sequencing of telomeres. Genome Biology. https://doi.org/10.1186/s13059-022-02751-6
Freeman, SS, … Meyerson, M & … (2022). Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma. Cell Reports. https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(21)00377-3?elqTrackId=12f8c20525ca4bc5af242e2621fa1b6e
Orsi, DL, … Meyerson, M, … & Goldstein, J (2022). Discovery and structure-based design of potent covalent PPARγ inverse-agonists BAY-4931 and BAY-0069. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.2c01379
Gao, GF, Oh, C, Saksena, G, … Meyerson, M, & … (2022). Tangent normalization for somatic copy-number inference in cancer genome analysis. Bioinformatics. https://academic.oup.com/bioinformatics/article-abstract/38/20/4677/6678978
Lee, S, … Cherniack, AD, Meyerson, M, & Greulich, H (2022). Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death. Nature Chemical Biology. https://doi.org/10.1038/s41589-022-01170-9
Nomburg, J, … Meyerson, M, & … (2022). Long-read sequencing reveals complex patterns of wraparound transcription in polyomaviruses. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1010401
Nomburg, J, … Meyerson, M, & … (2022). An international report on bacterial communities in esophageal squamous cell carcinoma. International Journal of Cancer. https://doi.org/10.1002/ijc.34212

2021

Lee, MN, & Meyerson, M (2021). Antigen identification for HLA class I–and HLA class II–restricted T cell receptors using cytokine-capturing antigen-presenting cells. Science Immunology. https://doi.org/10.1126/sciimmunol.abf4001
Carrot-Zhang, J, … & Meyerson, M (2021). Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations. Cancer Discovery. https://aacrjournals.org/cancerdiscovery/article-abstract/11/3/591/3322
Garvie, CW, Wu, X, … & Greulich, H (2021). Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nature Communications. https://www.nature.com/articles/s41467-021-24495-w
Spurr, LF, … Cherniack, AD, Li, YY, & ... (2021). Quantification of aneuploidy in targeted sequencing data using ASCETS. Bioinformatics. https://academic.oup.com/bioinformatics/article-abstract/37/16/2461/6008689
Carrot-Zhang, J, … & Meyerson, M (2021). Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway. Cell Reports. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00020-6
Tan, KT, … Meyerson, M, & … (2021). Haplotype-resolved germline and somatic alterations in renal medullary carcinomas. Genome Medicine. https://doi.org/10.1186/s13073-021-00929-4
Carrot-Zhang, J, … Cherniack, AD, & …(2021). Analytical protocol to identify local ancestry-associated molecular features in cancer. STAR Protocols. https://www.sciencedirect.com/science/article/pii/S266616672100472X
Mäkinen, N, … Meyerson, M & ... (2021). Genomic evolution in a patient with lung adenocarcinoma with a germline EGFR T790M mutation. JTO Clinical and Research Reports. https://www.sciencedirect.com/science/article/pii/S2666364321000059
Zhou, J, Wu, Z, Zhang, Z, … Meyerson, M, & … (2021). Pan-ERBB kinase inhibition augments CDK4/6 inhibitor efficacy in oesophageal squamous cell carcinoma. Gut. https://gut.bmj.com/content/71/4/665

2020

Carrot-Zhang, J, … Berger, AC, … Cherniack, AD, & … (2020). Comprehensive analysis of genetic ancestry and its molecular correlates in cancer. Cancer Cell. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30211-7
Nomburg, J, Meyerson, M, & … (2020). Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2. Genome Medicine. https://doi.org/10.1186/s13073-020-00802-w
Llabata, P, Mitsuishi, Y, …, Meyerson, M & ... (2020). Multi-omics analysis identifies MGA as a negative regulator of the MYC pathway in lung adenocarcinoma. Molecular Cancer Research. https://aacrjournals.org/mcr/article-abstract/18/4/574/90118
Zhang, Z, … & Meyerson, M (2020). Patterns of chromosome 18 loss of heterozygosity in multifocal ileal neuroendocrine tumors. Genes Chromosomes & Cancer. https://doi.org/10.1002/gcc.22850
Lamberti, G, Spurr, LF, … Meyerson, M, Cherniack, AD, & … (2020). Clinicopathological and genomic correlates of programmed cell death ligand 1 (PD-L1) expression in nonsquamous non-small-cell lung cancer. Annals of Oncology. https://doi.org/10.1016/j.annonc.2020.02.017
Nomburg, J, … Meyerson, M, & … (2020). Comprehensive metagenomic analysis of blastic plasmacytoid dendritic cell neoplasm. Blood. https://doi.org/10.1182/bloodadvances.2019001260
Touat, M, Li, YY, … Cherniack, AD, & … (2020). Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. https://doi.org/10.1038/s41586-020-2209-9
Wu, X, … Cherniack, AD, … Meyerson, M, & Greulich, H (2020). Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.RA119.011191

2019

Chen, H, Carrot-Zhang, J, … & Meyerson, M (2019). Genomic and immune profiling of pre-invasive lung adenocarcinoma. Nature. https://www.nature.com/articles/s41467-019-13460-3
Stover, EH,... & Meyerson, M (2019). Pooled genomic screens identify anti-apoptotic genes as targetable mediators of chemotherapy resistance in ovarian cancer. Molecular Cancer Research. https://aacrjournals.org/mcr/article-abstract/17/11/2281/89946
Hayes, TK, … Meyerson, M & … (2019). A functional landscape of resistance to MEK1/2 and CDK4/6 inhibition in NRAS-mutant melanoma. Cancer Research. https://aacrjournals.org/cancerres/article-abstract/79/9/2352/640672
Cai, D, … & Meyerson, M (2019). Identification and Characterization of Oncogenic SOS1 Mutations in Lung Adenocarcinoma. Molecular Cancer Research. https://aacrjournals.org/mcr/article-abstract/17/4/1002/269927
Lewis, TA, ... Greuilich, H, & Meyerson, M (2019). Optimization of PDE3A modulators for SLFN12-dependent cancer cell killing. ACS Medicinal Chemistry Letters. https://doi.org/10.1021/acsmedchemlett.9b00360

2018

Taylor, AM, ... & Meyerson, M (2018). Genomic and functional approaches to understanding cancer aneuploidy. Cancer cell. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30111-9?code=cell-site&innerTabgraphical_S1535610818301119=
Viswanathan, SR, Ha, G, ... & Meyerson, M (2018). Structural alterations driving castration-resistant prostate cancer revealed by linked-read genome sequencing. Cell. https://www.cell.com/cell/fulltext/S0092-8674(18)30648-2
Gannon, HS, Zou, T, ... & Meyerson, M (2018). Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nature. https://www.nature.com/articles/s41467-018-07824-4
Viswanathan, SR, ... & Meyerson, M (2018). Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nature. https://www.nature.com/articles/s41588-018-0155-3
Zhang, X, ... & Meyerson, M (2018). Somatic superenhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor. Cancer Discovery, https://aacrjournals.org/cancerdiscovery/article-abstract/8/1/108/112872
Walker, MA, ... & Meyerson, M (2018). GATK PathSeq: a customizable computational tool for the discovery and identification of microbial sequences in libraries from eukaryotic hosts. Bioinformatics. https://academic.oup.com/bioinformatics/article-abstract/34/24/4287/5048938

2017

Robertson, AG, Shih, J, & ... (2017). Integrative analysis identifies four molecular and clinical subsets in uveal melanoma. Cancer cell, https://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30295-7
Lu, X, … Meyerson, M, & … (2017). MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-16-1944
Bullman, S, ... & Meyerson, M (2017). Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science, https://doi.org/10.1126/science.aal5240
Adalsteinsson, VA, Ha, G, Freeman, SS, ... & Meyerson, M (2017). Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. Nature. https://www.nature.com/articles/s41467-017-00965-y
Cherniack, AD, & ... (2017). Integrated molecular characterization of uterine carcinosarcoma. Cancer cell, https://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30053-3
Imielinski, M, ... & Meyerson, M (2017). Insertions and deletions target lineage-defining genes in human cancers. Cell,, https://www.cell.com/cell/fulltext/S0092-8674(16)31741-X
Campbell, JD, … Meyerson, M & … (2017). Comparison of prevalence and types of mutations in lung cancers among black and white populations. JAMA Oncology https://jamanetwork.com/journals/jamaoncology/article-abstract/2598491
Goldstein, JT, ... & Meyerson, M (2017). Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer. Cancer Research, https://aacrjournals.org/cancerres/article-abstract/77/24/6987/624485

2016

Beroukhim, R, Zhang, X, & Meyerson, M (2016). Copy number alterations unmasked as enhancer hijackers. Nature Genetics. https://doi.org/10.1038/ng.3754
Campbell, JD, ... & Meyerson, M (2016). Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. Nature. https://www.nature.com/articles/ng.3564
Zhang, X, ... Cherniack, A, & Meyerson, M (2016). Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nature. https://www.nature.com/articles/ng.3470
Berger, AH, Brooks, AN, Wu, X, ... & Meyerson, M (2016). High-throughput phenotyping of lung cancer somatic mutations. Cancer Cell. https://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30282-3
de Waal, L, ... Greulich, H, & Meyerson, M (2016). Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nature Chemical Biology. https://www.nature.com/articles/nchembio.1984
Gannon, HS, ... & Meyerson, M (2016). Identification of an “exceptional responder” cell line to MEK1 inhibition: clinical implications for MEK-targeted therapy. Molecular Cancer Research. https://aacrjournals.org/mcr/article-abstract/14/2/207/89655
Shankar, GM, ... & Meyerson, M (2016). BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology. Acta Neuropathologica. https://doi.org/10.1007/s00401-015-1492-2
Pedamallu, CS, Bhatt, AS, ... & Meyerson, M (2016). Metagenomic characterization of microbial communities in situ within the deeper layers of the ileum in Crohn's disease. Cellular and Molecular Gastroenterology and Hepatology. https://www.sciencedirect.com/science/article/pii/S2352345X16300510
Lin, W, ... & Meyerson, M (2016). Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets. Cancer Biology & Therapy. https://doi.org/10.1080/15384047.2016.1250986

2015

Zhang, CZ, ... & Meyerson, M (2015). Chromothripsis from DNA damage in micronuclei. Nature. https://www.nature.com/articles/nature14493
Ramos, AH, ... Meyerson, M & …(2015). Oncotator: cancer variant annotation tool. Human Mutation. https://doi.org/10.1002/humu.22771
Guo, G, … Meyerson, M & ... (2015). Whole-Exome Sequencing Reveals Frequent Genetic Alterations in BAP1, NF2, CDKN2A, and CUL1 in Malignant Pleural Mesothelioma. Cancer Research. https://aacrjournals.org/cancerres/article-abstract/75/2/264/606428
Shankar, GM, ... & Meyerson, M (2015). Rapid intraoperative molecular characterization of glioma. JAMA Oncology. https://jamanetwork.com/journals/jamaoncology/article-abstract/2293209
Van de Wetering, M, … Meyerson, M, & … (2015). Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell. https://doi.org/10.1016/j.cell.2015.03.053
Arvey, A, … Meyerson, M, & … (2015). The tumor virus landscape of AIDS-related lymphomas. Blood. https://doi.org/10.1182/blood-2014-11-599951
Zhang, CZ, ... & Meyerson, M (2015). Calibrating genomic and allelic coverage bias in single-cell sequencing. Nature. https://www.nature.com/articles/ncomms7822
Lin, W, Watanabe, ... & Meyerson, M (2015). Dynamic epigenetic regulation by menin during pancreatic islet tumor formation. Molecular Cancer Research. https://aacrjournals.org/mcr/article-abstract/13/4/689/128585
Berrios, C, … Meyerson, M, & … (2015). Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors. Journal of Virology. https://doi.org/10.1182/blood-2014-11-599951
Bambury, RM, ... & Meyerson, M (2015). DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors. BMC Cancer. https://doi.org/10.1186/s12885-015-1192-2

2014

Berger, AH, … & Meyerson, M (2014). Oncogenic RIT1 mutations in lung adenocarcinoma. Oncogene. https://doi.org/10.1038/onc.2013.581
Bhatt, AS, … Meyerson, M, & … (2014). Brief Report: In Search of a Candidate Pathogen for Giant Cell Arteritis: Sequencing-Based Characterization of the Giant Cell Arteritis Microbiome. Arthritis & Rheumatology. https://doi.org/10.1002/art.38631
Choi, PS, & Meyerson, M (2014). Targeted genomic rearrangements using CRISPR/Cas technology. Nature communications. https://www.nature.com/articles/ncomms4728
The Cancer Genome Atlas Research Network, Meyerson, M, & … (2014). Comprehensive molecular profiling of lung adenocarcinoma. Nature. https://doi.org/10.1038/nature13385
Hoadley, KA, Yau, C, Wolf, DM, Cherniack, AD, … (2014). Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin. Cell. https://doi.org/10.1016/j.cell.2014.06.049
Francis, JM, Zhang, CZ, Maire, CL, … Meyerson, M & … (2014). EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing. Cancer. https://aacrjournals.org/cancerdiscovery/article-abstract/4/8/956/4553
Helman, E, Lawrence, MS, Stewart, C, … & Meyerson, M (2014). Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing. Genome. https://genome.cshlp.org/content/24/7/1053.short
Brooks, AN, … Meyerson, M, & … (2014). A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events. PloS one. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087361
Watanabe, H, Ma, Q, Meyerson, M, & ... (2014). SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas. The Journal of Clinical Investigation. https://www.jci.org/articles/view/71545
Pugh, TJ, ... Meyerson, M, & … (2014). Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA …. Oncogene. https://www.nature.com/articles/onc2014150
Imielinski, M, Greulich, H, … Meyerson, M, & … (2014). Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma. The Journal of Clinical Investigation. https://www.jci.org/articles/view/72763
Sharifnia, T, … & Meyerson, M (2014). Genetic modifiers of EGFR dependence in non-small cell lung cancer. PNAS. https://doi.org/10.1073/pnas.1412228112
Cho, J, Bass, AJ, … & Meyerson, M (2014). Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive …. Molecular cancer. https://doi.org/10.1186/1476-4598-13-141
Partfenov, M, Pedamallu, CS, … Meyerson, M, & … (2013). Characterization of HPV and host genome interactions in primary head and neck cancers. PNAS. https://doi.org/10.1073/pnas.1416074111

2013

Kostic, AD, … & Meyerson M (2013). Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host & Microbe. https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(13)00255-2
Zack, TI, Schumacher, SE, … Meyerson, M, & … (2013). Pan-cancer patterns of somatic copy number alteration. Nature Genetics. https://www.nature.com/articles/ng.2760.pdf
Pugh, TJ, Morozova, O, … Meyerson, M, & … (2013). The genetic landscape of high-risk neuroblastoma. Nature Genetics. https://www.nature.com/articles/ng.2529
Chmielecki, J, Crago, AM, … & Meyerson, M (2013). Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nature Genetics. https://www.nature.com/articles/ng.2522
Liao, RG, Jung, J, Tchaicha, J, Wilkerson, MD, … Meyerson, M, & … (2013). Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Research. https://aacrjournals.org/cancerres/article-abstract/73/16/5195/657498
Abazeed, ME, Adams, DJ, ... Meyerson, M (2013). Integrative radiogenomic profiling of squamous cell lung cancer. Cancer Research. https://aacrjournals.org/cancerres/article-abstract/73/20/6289/585069
Cho, J, & ... Meyerson, M (2013). Cetuximab response of lung cancer–derived EGF receptor mutants is associated with asymmetric dimerization. Cancer Research. https://aacrjournals.org/cancerres/article-abstract/73/22/6770/585777
Bhatt, AS, … & Meyerson, M (2013). Sequence-Based Discovery of Bradyrhizobium enterica in Cord Colitis Syndrome. The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa1211115
Watanabe, H, … & Meyerson, M (2013). Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes & Development. https://genesdev.cshlp.org/content/27/2/197.short
Kim, Y, Hammerman, PS, … Meyerson, M, & … (2013). Integrative and Comparative Genomic Analysis of Lung Squamous Cell Carcinomas in East Asian Patients. Journal of Clinical Oncology. https://doi.org/10.1200/JCO.2013.50.8556
Ojesina, AI, … & Meyerson, M (2013). Landscape of genomic alterations in cervical carcinomas. Nature. https://doi.org/10.1038/nature12881

2012

Imielinski, M, Berger, AH, Hammerman, PS, Hernandez, B, Pugh, TJ, … & Meyerson, M (2012). Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell. https://www.cell.com/fulltext/S0092-8674(12)01061-6
Kostic, AD, ... Meyerson, M (2012). Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Research. https://genome.cshlp.org/content/22/2/292.short
Carter, SL, Cibulskis, K, Helman, E, McKenna, A, ... Meyerson, M, & … (2012). Absolute quantification of somatic DNA alterations in human cancer. Nature Biotechnology. https://www.nature.com/articles/nbt.2203
Banerji, S, Cibulskis, K, Rangel-Escareno, C, Brown, KK, … & Meyerson, M (2012). Sequence analysis of mutations and translocations across breast cancer subtypes. Nature. https://www.nature.com/articles/nature11154
Pugh, TJ, ... Meyerson, M, & … (2012). Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature. https://www.nature.com/articles/nature11329
Verhaak, RGW, ... Meyerson, M, & … (2012). Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. The Journal of Clinical Investigation. https://www.jci.org/articles/30804
Greulich, H, ... & Meyerson, M (2012). Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. PNAS. https://doi.org/10.1073/pnas.1203201109
The Cancer Genome Atlas Research Network, Meyerson, M, … (2012). Comprehensive genomic characterization of squamous cell lung cancers. Nature. https://doi.org/10.1038/nature11404

2011

Cho, YJ, Tsherniak, A, Tamayo, P, Santagata, S, … Meyerson, M, & … (2011). Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2010.28.5148
Bass, AJ, Lawrence, MS, ... & Meyerson, M (2011). Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature Genetics. https://www.nature.com/articles/ng.936
Dutt, A, ... & Meyerson, M (2011). Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer. PloS one., https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020351
Kostic, AD, ... & Meyerson, M (2011). PathSeq: software to identify or discover microbes by deep sequencing of human tissue. Nature Biotechnology. https://www.nature.com/articles/nbt.1868
Lin, W, Cao, J, … Meyerson, M, & … (2011). Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. PNAS. https://doi.org/10.1073/pnas.1110104108
Cho, J, ... & Meyerson, M (2011). Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies. Cancer Research. https://aacrjournals.org/cancerres/article-abstract/71/24/7587/570329
Carter, S, Meyerson, M, & Getz, G (2011). Accurate estimation of homologue-specific DNA concentration-ratios in cancer samples allows long-range haplotyping. Nature Precedings., https://www.nature.com/articles/npre.2011.6494.1
Francis, J, … & Meyerson, M (2011). The Menin Tumor Suppressor Protein is Phosphorylated in Response to DNA Damage. PLoS One. https://doi.org/10.1371/journal.pone.0016119
Hammerman, PS, … Greulich, H, Bass, AJ, … Thomas, RK, & Meyerson, M (2011). Mutations in DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer. Cancer Discovery. https://doi.org/10.1158/2159-8274.CD-11-0005
Mermel, CH, … Meyerson, M … (2011). GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biology. https://doi.org/10.1186/gb-2011-12-4-r41

2010

Beroukhim, R, Mermel, CH, … & Meyerson, M (2010). The landscape of somatic copy-number alteration across human cancers. Nature. https://www.nature.com/articles/nature08822
Verhaak, RGW, … Meyerson, M, Getz, G & ... (2010). Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer cell. https://www.cell.com/cancer-cell/fulltext/S1535-6108(09)00432-2
Barretina, J, … Meyerson, M & … (2010). Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nature. https://www.nature.com/articles/ng.619

2009

Bass, AJ, Watanabe, H, … & Meyerson, M (2009). SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature. https://www.nature.com/articles/ng.465
Chiang, DY, Getz, G, … Meyerson, M & … (2009). High-resolution mapping of copy-number alterations with massively parallel sequencing. Nature. https://www.nature.com/articles/nmeth.1276
Beroukhim, R, … Meyerson, M & … (2009). Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer …, aacrjournals.org, https://aacrjournals.org/cancerres/article-abstract/69/11/4674/549656
Rozenblatt-Rosen, O, … & Meyerson, M (2009). The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors. PNAS.https://doi.org/10.1073/pnas.0812023106
Ramos, AH, … & Meyerson, M (2009). Amplification of chromosomal segment 4q12 in non-small cell lung cancer. Cancer biology & …, Taylor & Francis, https://doi.org/10.4161/cbt.8.21.9764

2008

The Cancer Genome Atlas Research Network, Meyerson, M, … (2008). Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. https://doi.org/10.1038/nature07385
Ding, L, … Meyerson, M, & … (2008). Somatic mutations affect key pathways in lung adenocarcinoma. Nature. https://doi.org/10.1038/nature07423
Dutt, A, … Meyerson, M, & Greulich, H (2008). Drug-sensitive FGFR2 mutations in endometrial carcinoma. PNAS. https://doi.org/10.1073/pnas.0803379105
George, RE, … Greulich, H, … Meyerson, M, & … (2008). Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature, nature.com, https://www.nature.com/articles/nature07397
Chiang, DY, … Meyerson, M, & … (2008). Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma. Cancer …, aacrjournals.org, https://aacrjournals.org/cancerres/article-abstract/68/16/6779/540746
Li, C, … & Meyerson, M (2008). Major copy proportion analysis of tumor samples using SNP arrays. BMC …, Springer, https://doi.org/10.1186/1471-2105-9-204

2007

Weir, BA, … & Meyerson, M (2007). Characterizing the cancer genome in lung adenocarcinoma. Nature. https://doi.org/10.1038/nature06358
Thomas, RK, … Meyerson, M, & ... (2007). High-throughput oncogene mutation profiling in human cancer. Nature. https://www.nature.com/articles/ng1975
Minami, Y … Meyerson, M, & Thomas, RK (2007). The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272. Oncogene, nature.com, https://www.nature.com/articles/1210292
Yuza, Y, … & Meyerson, M (2007). Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors. Cancer biology & …, Taylor &Francis, https://doi.org/10.4161/cbt.6.5.4003

2006

Lee, JC, … Meyerson, M, & … (2006). Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS …, journals.plos.org, https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0030485
Hayes, DN, … & Meyerson, M (2006). Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts. Journal of Clinical …, ascopubs.org, https://doi.org/10.1200/JCO.2005.05.1748
Thomas, RK, … & Meyerson, M (2006). Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nature Medicine. https://doi.org/10.1038/nm1437
Ji, H, Zhao, X, … Meyerson, M & … (2006). Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. PNAS.https://doi.org/10.1073/pnas.0510284103
MacConaill, LE, … & Meyerson, M (2006). Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583. Molecular cancer …, aacrjournals.org, https://aacrjournals.org/mcr/article-abstract/4/10/793/232728

2005

Greulich, H, … & Meyerson, M (2005). Oncogenic transformation by inhibitor-sensitive and-resistant EGFR mutants. PLoS …, journals.plos.org, https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020313
Zhao, X, … & Meyerson, M (2005). Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer …, aacrjournals.org, https://aacrjournals.org/cancerres/article-abstract/65/13/5561/518298
LaFramboise, T, … & Meyerson, M (2005). Allele-specific amplification in cancer revealed by SNP array analysis. PLoS Computational …, journals.plos.org, https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.0010065
Thomas, RK, … & Meyerson, M (2005). Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors. Cold Spring Harbor …, symposium.cshlp.org, https://symposium.cshlp.org/content/70/73.short

2004

Rozenblatt-Rosen, O, … & Meyerson, M (2005). The Parafibromin Tumor Suppressor Protein is Part of a Human Paf1 Complex. Molecular and Cellular Biology. https://doi.org/10.1128/MCB.25.2.612-620.2005
Zhao, X, ... & Meyerson, M (2004). An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Research. https://aacrjournals.org/cancerres/article-abstract/64/9/3060/517887
Paez, JG, ... Meyerson, M (2004). EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy. Science. https://doi.org/10.1126/science.1099314
Scacheri, PC, Rozenblatt-Rosen, O, … Bhattacharjee, A, Meyerson, M, & … (2004). Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. PNAS. https://doi.org/10.1073/pnas.0308698100
Jänne, PA, … & Meyerson, M (2004). High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines. Oncogene. https://doi.org/10.1038/sj.onc.1207329
Hughes, CM, Rozenblatt-Rosen, O, ... & Meyerson, M (2004). Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Molecular Cell. https://www.cell.com/molecular-cell/fulltext/S1097-2765(04)00081-4
Tengs, T, ... & Meyerson, M (2004). Genomic representations using concatenates of Type IIB restriction endonuclease digestion fragments. Nucleic Acids Research. https://academic.oup.com/nar/article-abstract/32/15/e121/2375764

2000-2003

Xu, Y, ... Meyerson, M (2003). Pathogen discovery from human tissue by sequence-based computational subtraction. Genomics, Elsevier, https://www.sciencedirect.com/science/article/pii/S0888754302000435
Naoki, K, ... Meyerson, M (2002). Missense Mutations of the BRAF Gene in Human Lung Adenocarcinoma. Cancer Research. https://aacrjournals.org/cancerres/article-abstract/62/23/7001/509533
Weber, G, ... Meyerson, M (2002). Identification of foreign gene sequences by transcript filtering against the human genome. Nature Genetics. https://www.nature.com/articles/ng818z
Bhattacharjee, A, … Meyerson, M (2001). Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. PNAS. https://doi.org/10.1073/pnas.191502998
Lindblad-Toh, K, ... Meyerson, M (2000). Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nature Biotechnology. https://www.nature.com/articles/nbt0900_1001
Stanton, SE, … Meyerson, M (2000). Recurrent allelic deletions of chromosome arms 15q and 16q in human small cell lung carcinomas. Genes Chromosomes & Cancer. https://doi.org/10.1002/(SICI)1098-2264(200003)27:3%3C323::AID-GCC14%3E3.0.CO;2-P

Pre-2000

Hahn, WC, ... Meyerson, M, & … (1999). Inhibition of telomerase limits the growth of human cancer cells. Nature Medicine. https://www.nature.com/articles/nm1099_1164
Counter, CM, Meyerson, M, & ... (1998). Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene. https://www.nature.com/articles/1201882
Kolquist, ... Meyerson, M, & ... (1998). Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nature Genetics. https://www.nature.com/articles/ng0698_182
Meyerson, M, & ... (1997). hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell. https://www.cell.com/cell/fulltext/S0092-8674(00)80538-3
Counter, CM, Meyerson, M, & ... (1997). The catalytic subunit of yeast telomerase. PNAS. https://doi.org/10.1073/pnas.94.17.9202
Meyerson, M, & Harlow, ED (1994). Identification of G1 Kinase Activity for cdk6, a Novel Cyclin D Partner. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.14.3.2077-2086.1994
Meyerson, M, & ... (1992). A family of human cdc2‐related protein kinases.. The EMBO Journal. https://pmc.ncbi.nlm.nih.gov/articles/PMC556772/
Tsai, LH, Harlow, E, & Meyerson, M (1991). Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. https://www.nature.com/articles/353174a0

Lab & collaborative articles are all Meyerson laboratory publications, as well as publications led by other groups, where a member or members of the Meyerson Laboratory shares authorship.