Mills Lab Publications
2026
Ng MY, Nix MN, Du G, Davidek I, Burger N, Shin S, Toenjes S, Takeda H, Cheah Xin Yan M, Zhang B, Xiao H, Wei SM, Seo HS, Dhe-Paganon S, Wales TE, Engen JR, Mills EL, Che J, Zhang T, Gray NS, Chouchani ET. A druggable redox switch on SHP1 controls macrophage inflammation.
Nature Chemical Biology
2025
Xiao H, Ordonez M, Fink EC, Covington TA, Woldemichael HB, Chen J, Jain MS, Rohatgi MH, Wei SM, Burger N, Sharif MA, Jan J, Wang Y, Petrocelli JJ, Blackmore K, Smythers AL, Zhang B, Gilbert M, Cheong H, Khetarpal SA, Smith A, Bogoslavski D, Lei Y, Vaites LP, McAllister FE, Van Bruggen N, Donovan KA, Huttlin EL, Mills EL, Fischer ES, Chouchani ET. Covariation MS uncovers a protein that controls cysteine catabolism.
Nature
Kunkemoeller B, Prendeville H, McIntyre C, Temesgen A, Loftus RM, Yao C, Dyck L, Sinclair LV, Rollings C, Douglas A, Pernes G, Mitchelson KAJ, Harmon C, Raverdeau M, Ward R, Kane H, Kline J, O'Brien KL, Brennan M, Smith F, Stevens B, Roche HM, Lavelle EC, Finlay DK, Cantrell DA, Chouchani ET, Kaech S, Mills EL, Haigis M, Lynch L. The source of dietary fat influences anti-tumour immunity in obese mice.
Nature Metabolism
Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Smythers AL, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Paulo JA, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM. Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST.
Cell Metabolism
Prenen F, Pollenus E, Meers H, Knoops S, Sadler R, Deckers M, Mills EL, Van den Steen PE. Itaconate Has Limited Protective Effects in Experimental Malaria Models.
European Journal of Immunology
2024
Tran N & Mills EL. Redox regulation of macrophages.
Redox Biology
Verkerke ARP, Wang D, Yoshida N, Taxin ZH, Shi X, Zheng S, Li Y, Auger C, Oikawa S, Yook JS, Granath-Panelo M, He W, Zhang GF, Matsushita M, Saito M, Gerszten RE, Mills EL, Banks AS, Ishihama Y, White PJ, McGarrah RW, Yoneshiro T, Kajimura S. BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis.
Cell
Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, Smith A, Ordonez M, Laznik-Bogoslavski D, Rothstein JD, Mills EL, Chouchani ET. Monocarboxylate transporters facilitate succinate uptake into brown adipocytes.
Nature Metabolism
2023
Darabedian N, Ji W, Fan M, Lin S, Seo H-S, Vinogradova EV, Yaron TM, Mills EL, Xiao H, Senkane K, Huntsman EM, Johnson JL, Che J, Cantley LC, Cravatt BF, Dhe-Paganon S, Stegmaier K, Zhang T, Gray NS, Chouchani ET. Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.
Nature Chemical Biology
Liu W, Wang Y, Bozi LHM, Fischer P, Jedrychowski MP, Xiao H, Wu T, Darabedian N, He X, Mills EL, Burger N, Shin S, Reddy A, Sprenger HG, Tran N, Winther S, Hinshaw SM, Shen J, Seo HS, Song K, Xu AZ, Sebastian L, Zhao J, Dhe-Paganon S, Che J, Gygi SP, Arthanari H, Chouchani ET. Lactate regulates cell cycle by remodeling the anaphase promoting complex.
Nature
2022
Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O’Shea D, Brennan D, Lynch L. Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Journal of Experimental Medicine
Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, Vitas LP, Laznik-Bogoslavski D, Ordonez M, Liu X, Chen X, Wang Y, Liu W, Tran N, Liu Y, Zhang Y, Cypess AM, White AP, He Y, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ET. Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
Cell
Mills EL, Chouchani ET. Career pathways, part 9.
Nature Metabolism
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Bradshaw GA, Tran N, Garrity R, Szpyt J, Prendeville H, Lynch L, Gygi SP, Spiegelman BM, Chouchani ET.
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Cell Metabolism
2021
Williams NC, Ryan DG, Costa ASH, Mills EL, Jedrychowski MP, Cloonan SM, Frezza C, O’Neill LA.
Signalling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages.
Journal of Biological Chemistry
Guillot-Sestier MV, Araiz RA, Mela V, Gaban AS, O’Neill E, Joshi L, Chouchani ET, Mills EL, Lynch MA.
Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease.
Communication Biology
Mills EL, Harmon H, Jedrychowski MP, Xiao H, Garrity R, Tran N, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET.
UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
Nature Metabolism
Mills EL, Xiao H, Chouchani ET.
AIDA and UCP1 snuggle up to prevent hypothermia.
Nature Cell Biology
2020
Reddy A, Bozi LHM, Yaghi OK, Mills EL, Xiao H, Nicholson HE, Paschini M, Paulo JA, Garrity R, Laznik-Bogoslavski S, Ferreira JCB, Carl CS, Sjøberg KA, Wojtaszewski JFP, Jeppesen JF, Kiens B, Gygi SP, Richter EA, Mathis D, Chouchani ET.
pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise.
Cell
Xiao H, Jedrychowski MP, Schweppe DK, Huttlin EL, Yu Q, Heppner DE, Li J, Long J, Mills EL, Szpyt J, He Z, Du G, Garrity R, Reddy A, Vaites LP, Paulo JA, Zhang T, Gray NS, Gygi SP, Chouchani ET.
A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging.
Cell
Madala HR, Helenius IT, Zhou W, Mills EL, Zhang Y, Liu Y, Metelo AM, Kelley ML, Punganuru S, Kim KB, Olenchock B, Rhee E, Intlekofer AM, Iliopoulos O, Chouchani E, Yeh JJ.
Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction.
Cancer Research
Mills EL, O’Neill LAJ.
Not All Mitochondrial Cristae Are the Same: Hetero-Potential in the Inner Mitochondrial Membrane.
Immunometabolism
2019
Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.
Coupling Krebs cycle metabolites to signalling in immunity and cancer.
Nature Metabolism
2018
Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET.
Accumulation of systemic succinate controls activation of adipose tissue thermogenesis.
Nature
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Nature
2017
Mills EL, Kelly B, O'Neill LAJ.
Mitochondria are the powerhouses of immunity.
Nature Immunology
Patel MN, Carroll RG, Galván-Peña S, Mills EL, Olden R, Triantafilou M, Wolf AI, Bryant CE, Triantafilou K, Masters SL. Inflammasome Priming in Sterile Inflammatory Disease.
Trends in Molecular Medicine
Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AA, Cooper MA, O'Neill LA, Lynch MA. Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.
Brain, Behavior, and Immunity
2016
Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, Tourlomousis P, Däbritz JHM, Gottlieb E, Latorre I, Corr SC, McManus G, Ryan D, Jacobs HT, Szibor M, Xavier RJ, Braun T, Frezza C, Murphy MP, O'Neill LA.
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Cell
Mills EL and O'Neill LA.
Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal.
European Journal of Immunology
2014
Mills E and O'Neill LA.
Succinate: a metabolic signal in inflammation.
Trends in Cell Biology
2012
Cunningham CC, Mills E, Mielke LA, O'Farrell LK, Lavelle E, Mori A, McCarthy GM, Mills KH, Dunne A.
Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase.
Clinical Immunology