Pellman Lab

Cell Division and Genome Instability

Our laboratory studies cell division, cell division and chromosome segregation errors in cancer, and the impact of these errors on cancer genome structure. We use genetics, biochemistry and live-cell imaging. We developed a method to combine long-term live-cell imaging with single cell isolation and single cell genomics (Look-Seq). Look-Seq enables morphological phenotype to be directly related to a cell’s genotype.  With these approaches we recreate and dissect catastrophic mutational processes, common in cancer, that drive rapid genome evolution.