Matthew Leventhal

Education:

Bowdoin College, BA Biology and Mathematics (double major), Brunswick, Maine

Massachusetts Institute of Technology PhD Computational and Systems Biology, Cambridge Massachusetts

Awards and Honors:

Barbara Weedon Fellowship (2023)

Selected Publications:

M Leventhal, Zanella CA, Kang B, Jiajie Peng J, David Gritsch, Zhixiang Liao, et al. 2025. An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration. Nature Communications. 16 (1): 1-21. https://doi.org/10.1038/s41467-025-59654-w.

JT Stocksdale*, Leventhal M* (*co-first author), Stephanie Lam, Yu-Xin Xu, Keona Q. Wang, Yogindra Raghav, et al. 2025. Intersecting impact of CAG repeat and huntingtin knockout in stem cell-derived cortical neurons. Neurobiology of Disease. 210: 106914. https://doi.org/10.1016/j.nbd.2025.106914

V Nithianandam, Bukhari H, Leventhal MJ, Battaglia R, Dong X, Fraenkel E, and Feany MB. 2023. Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging. Nature Communications. 14(7034): 1-19

TH Mouhieddine, Sperling AS, Redd R, Park J, Leventhal M, Gibson CJ et al. 2020. Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Nature Communications. 11: 1-9.

AG Bick, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM…Leventhal M…Natarajan P. 2020. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 586: 763-768.

S Boettcher, Miller PG, Sharma R, McConkey M, Leventhal M, Yang X, et al. 2019. A dominant-negative effect drives selection of TP53 missense mutations in acute myeloid leukemia. Science. 365 (6453): 599-604.

E Beauchamp, Leventhal M, Bernard E, Hoppe E, Todisco G, Creignou M, Galli A, et al. 2021. ZBTB33 is Mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA Splicing. Blood Cancer Discovery. 2(5): 500-517.

M Jan, Leventhal MJ, Morgan EA, Wengrod JC, Nag A, Drinian SD, et al. 2019. Recurrent genetic HLA loss in Acute Myeloid Leukemia relapsed after matched unrelated allogeneic hematopoietic cell transplant. Blood Advances. 3 (14): 2199–2204.