Qi Lab Publications
View all research publications from the Qi laboratory.
Selected Publications
2026
Selective histone deacetylase inhibition as a therapeutically relevant strategy in H3K27M-glioma.
Groves A,* Kirkland OO,* Cascio CL, Wang X, Heaslip C, Marques JG, Song C, Poetschke R, Wang T, Chin DH, Asante Y, Liu Q, Kim H, Gu S, Trissal M, Labelle J, Cruzeiro GAV, Jones KL, Cameron AB, Clark LM, Leeper B, Nguyen QD, Gryder BE, Filbin MG,‡ Qi J.‡ Neuro Oncology 2026 Jun 25:noag142. doi: 10.1093/neuonc/noag142. Online ahead of print.PMID: 42351295 Free article.
Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma.
Agius MP,* Song C,* Liu Q, Iemura T, Hevenor L, Payne NC, Pistofidis RS, Pantano L, Zhao H, Seo HS, Heilpern-Mallory D, Heaslip C, Sun ZJ, Bashyal P, Aranha MP, Lightbody E, Mazitschek R, Dhe-Paganon S, Mitsiades CS, Ghobrial IM,‡ Qi J.‡ Nature Chemical Biology. 2026 May 28. doi: 10.1038/s41589-026-02228-8. Online ahead of print. PMID: 42209806
Proteasome Cap Targeting Chimeras for Ubiquitination-Independent Targeted Protein Degradation.
Song C,* Liu Q,* Wang T,* Song Y,* Sigua LH, Park PM, Ficarro S, Lee S, Picaud S, Filippakopoulos P, Marto JA, Kostic M, Durbin AD, Anderson K,‡ Qi J.‡ Angewandte Chemie International Edition English. 2026 Jan 20:e20039. doi: 10.1002/anie.202520039. Online ahead of print. PMID: 41556619
Nutrient-driven histone acetylation underlies energy storage and mobilization.
Chen L, Zhu L, Xiao H, Wang X, Xia F, Wang Z, Wu L, Wu D, Liu Q, Cheng J, Qi J,‡ Duan Q.‡ Molecular Metabolism. 2026 Apr;106:102344. doi: 10.1016/j.molmet.2026.102344. Epub 2026 Mar 3.PMID: 41786244 Free PMC article.
Chemical Perturbations Impacting Histone Acetylation Govern Colorectal Cancer Differentiation.
Likasitwatanakul P, Li Z, Doan P, Spisak S, Raghawan AK, Liu Q, Liow P, Lee S, Chen D, Bala P, Sahgal P, Aitymbayev D, Thalappillil JS, Papanastasiou M, Hawkins W, Carr SA, Park H, Cleary JM, Qi J*, Sethi NS*. Gastroenterology. 2026 Jan;170(1):70-88. doi: 10.1053/j.gastro.2025.07.003. Epub 2025 Jul 7.PMID: 40633623
Structural Basis for BD1-Preferring 2,4-Disubstituted Pyrimidine BRDT Inhibitors.
Liang T, Guan X, Chan A, Kalra P, Shi R, Solberg J, Sigua LH, Qi J, Pomerantz WCK, Schönbrunn E, Hawkinson JE, Georg GI. J Med Chem. 2026 May 14;69(9):11088-11108. doi: 10.1021/acs.jmedchem.6c00180. Epub 2026 Apr 15.PMID: 41984625 Free PMC article.
Dominant clones leverage developmental epigenomic states to drive ependymoma.
Kardian AS, Sun H, Ippagunta S, Laboe N, Varadharajan S, Yu K, Chen HC, Emanus E, Zheng T, Deneen RM, Connelly JP, Wang YD, Zhan J, Liu H, Lowe K, Bugbee T, Pathak R, Bland A, Mehta S, Cochiolo S, Arabzade A, Holcomb B, Budd KM, Kembuan G, Wright T, Caesar E, Park M, Hancock A, Gee D, Murdoch J, Xiao Y, McBrayer SK, Merchant TE, Qi J, Durbin AD, Schwarz LA, Wang L, Donson AM, Foreman NK, Agnihotri S, Lavado A, Baker SJ, Ellison DW, Lee HK, Pruett-Miller SM, Bertrand KC, Deneen B, Mack SC. Nature. 2026 Apr;652(8111):1027-1037. doi: 10.1038/s41586-026-10270-8. Epub 2026 Mar 25.PMID: 41882368 Free PMC article.
2025
Total Synthesis and Anticancer Study of (+)-Verticillin A.
Knauss W, Wang X, Filbin MG, Qi J*, Movassaghi M*. Journal of American Chemical Society. 2025 Dec 17;147(50):46430-46439. doi: 10.1021/jacs.5c16112. PMID: 41329819
Barreto-Galvez A, Niljikar M, Gagliardi JE, Guzman CP, Zhang R, Kumar V, Juwarwala A, Pradeep A, Saxena A, Montagna C, Mittal P, Gerhardt J, Xia B, Cao J, Kataoka K, Durbin AD, Qi J, Ye BH, Madireddy A. Nat Commun. 2025 Dec 7;17(1):475. doi: 10.1038/s41467-025-67171-z.PMID: 41354653
St Laurent JD, Xu GD, Ying AW, Gokbayrak B, Patil A, Paulo JA, Cervantes KS, Chen S, Feng WW, Sankar A, Samé Guerra DD, Qi J, Neel DS, Hornick JL, Kolin DL, Gygi SP, Hunstman DG, Wang Y, Kadoch C. Nat Genet. 2025 Nov;57(11):2743-2755. doi: 10.1038/s41588-025-02333-9. Epub 2025 Oct 20.PMID: 41116019
Zhou X, Moreira S, Restelli C, Wang H, Jahangiri S, Aryal S, Tsao E, Zhang P, Niu M, Kumar H, Balde Z, Vujovic A, Liu L, Wong N, Arruda A, Minden MD, Zhou Y, Ravi B, Qi J, Li C, Hope KJ, Lu R. Sci Transl Med. 2025 Aug 6;17(810):eadn5400. doi: 10.1126/scitranslmed.adn5400. Epub 2025 Aug 6.PMID: 40768599
Godfrey LC, Regalado B, Schweber SR, Hatton C, Wenge DV, Wen Y, Boileau M, Wessels M, Qi J, Ott CJ, Stegmaier K, Rivera MN, Armstrong SA. EMBO Rep. 2025 Oct;26(19):4766-4793. doi: 10.1038/s44319-025-00552-z. Epub 2025 Sep 1. PMID: 40890402
Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer.
Hong D, Lyu Y, Nayak R, Becker JS, Booker MA, Masuzawa K, Devos Z, Wang T, Saito S, Liu Q, Li Y, Li Z, Knelson EH, Thai T, Duplaquet L, Laimon YN, Roberti De Oliveira G, Signoretti S, Doench JG, Barbie DA, Tolystorukov MY, Qi J, Bernstein BE, Ge Y, Oser MG. Dev Cell. 2025 Dec 15;60(24):3462-3479.e13. doi: 10.1016/j.devcel.2025.07.023. Epub 2025 Aug 26. PMID: 40865518
Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
Hassan MM, Li YD, Ma MW, Teng M, Byun WS, Puvar K, Lumpkin R, Sandoval B, Rutter JC, Jin CY, Wang MY, Xu S, Schmoker AM, Cheong H, Groendyke BJ, Qi J, Fischer ES, Ebert BL, Gray NS.Eur J Med Chem. 2024 Dec 5;279:116904. doi: 10.1016/j.ejmech.2024.116904. Epub 2024 Sep 24.PMID: 39341093
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming.
Gritti I, Wan J, Weeresekara V, Vaz JM, Tarantino G, Bryde TH, Vijay V, Kammula AV, Kattel P, Zhu S, Vu P, Chan M, Wu MJ, Gordan JD, Patra KC, Silveira VS, Manguso RT, Wein MN, Ott CJ, Qi J, Liu D, Sakamoto K, Gujral TS, Bardeesy N.
2024
KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells.
Li TW, Park Y, Watters EG, Wang X, Zhou D, Fiches GN, Wu Z, Badley AD, Sacha JB, Ho WZ, Santoso NG, Qi J,* Zhu J.* Antiviral Research. 2024 Aug;228:105947. doi: 10.1016/j.antiviral.2024.105947. Epub 2024 Jun 24.PMID: 38925368
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition.
Shendy NAM#, Bikowitz M#, Sigua LH#, Zhang Y, Mercier A, Khashana Y, Nance S, Liu Q, Delahunty IM, Robinson S, Goel V, Rees MG, Ronan MA, Wang T, Kocak M, Roth JA, Wang Y, Freeman BB, Orr BA, Abraham BJ, Roussel MF, Schonbrunn E*, Qi J*, Durbin AD*. Nature Communication. 2024 Apr 25;15(1):3483. doi: 10.1038/s41467-024-47102-0.PMID: 38664416
Template-assisted covalent modification underlies activity of covalent molecular glues.
Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Rutter JC, Lumpkin RJ, Sandoval B, Jin CY, Schmoker AM, Ficarro SB, Cheong H, Metivier RJ, Wang MY, Xu S, Byun WS, Groendyke BJ, You I, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Sperling HT, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL.Nat Chem Biol. 2024 Jul 29. doi: 10.1038/s41589-024-01668-4. Online ahead of print.PMID: 39075252
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer.
Duplaquet L, So K, Ying AW, Pal Choudhuri S, Li X, Xu GD, Li Y, Qiu X, Li R, Singh S, Wu XS, Hamilton S, Chien VD, Liu Q, Qi J, Somerville TDD, Heiling HM, Mazzola E, Lee Y, Zoller T, Vakoc CR, Doench JG, Forrester WC, Abrams T, Long HW, Niederst MJ, Drapkin BJ, Kadoch C, Oser MG.Cancer Cell. 2024 Aug 12;42(8):1352-1369.e13. doi: 10.1016/j.ccell.2024.06.012. Epub 2024 Jul 18.PMID: 39029464
Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system.
Spisak S, Chen D, Likasitwatanakul P, Doan P, Li Z, Bala P, Vizkeleti L, Tisza V, De Silva P, Giannakis M, Wolpin B, Qi J, Sethi NS. Nat Commun. 2024 Mar 12;15(1):2230. doi: 10.1038/s41467-024-46285-w.PMID: 38472198 Free PMC article.
BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma.
Feng Y, Cai L, Pook M, Liu F, Chang CH, Mouti MA, Nibhani R, Militi S, Dunford J, Philpott M, Fan Y, Fan GC, Liu Q, Qi J, Wang C, Hong W, Morgan H, Wang M, Sadayappan S, Jegga AG, Oppermann U, Wang Y, Huang W, Jiang L, Pauklin S. Gastroenterology. 2024 Jan;166(1):139-154.
2023
A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics.
Lee HM, Wright WC, Pan M, Low J, Currier D, Fang J, Singh S, Nance S, Delahunty I, Kim Y, Chapple RH, Zhang Y, Liu X, Steele JA, Qi J, Pruett-Miller SM, Easton J, Chen T, Yang J, Durbin AD, Geeleher P. Nat Commun. 2023 Nov 13;14(1):7332 doi: 10.1038/s41467-023-43134-0.PMID: 37957169
Combination therapies to improve the efficacy of immunotherapy in triple-negative breast cancer.
Alečković M, Li Z, Zhou N, Qiu X, Lulseged B, Foidart P, Huang XY, Garza K, Shu S, Kesten N, Li R, Lim K, Garrido-Castro AC, Guerriero JL, Qi J, Long HW, Polyak K.Mol Cancer Ther. 2023 Sep 7. doi: 10.1158/1535-7163.MCT-23-0303. Online ahead of print. PMID: 37676980
Manipulating Tyrosine Phosphorylation by Heterobifunctional Small Molecules.
Meng X, Qi J. ACS Cent Sci. 2023 Aug 15;9(8):1512-1514. doi: 10.1021/acscentsci.3c00836. eCollection 2023 Aug 23.PMID: 37637739 Free PMC article.
Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer.
de Miguel FJ, Gentile C, Feng WW, Silva SJ, Sankar A, Exposito F, Cai WL, Melnick MA, Robles-Oteiza C, Hinkley MM, Tsai JA, Hartley AV, Wei J, Wurtz A, Li F, Toki MI, Rimm DL, Homer R, Wilen CB, Xiao AZ, Qi J, Yan Q, Nguyen DX, Jänne PA, Kadoch C, Politi KA.Cancer Cell. 2023 Aug 14;41(8):1516-1534.e9. doi: 10.1016/j.ccell.2023.07.005. Epub 2023 Aug 3.PMID: 37541244 Free article.
Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis.
Li M, Yang L, Chan AKN, Pokharel SP, Liu Q, Mattson N, Xu X, Chang WH, Miyashita K, Singh P, Zhang L, Li M, Wu J, Wang J, Chen B, Chan LN, Lee J, Zhang XH, Rosen ST, Müschen M, Qi J, Chen J, Hiom K, Bishop AJR, Chen CW. Adv Sci (Weinh). 2023 Jun;10(17):e2206584. doi: 10.1002/advs.202206584. Epub 2023 Apr 19.PMID: 37075745 Free PMC article.
Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion.
Battistello E, Hixon KA, Comstock DE, Collings CK, Chen X, Rodriguez Hernaez J, Lee S, Cervantes KS, Hinkley MM, Ntatsoulis K, Cesarano A, Hockemeyer K, Haining WN, Witkowski MT, Qi J, Tsirigos A, Perna F, Aifantis I, Kadoch C. Mol Cell. 2023 Apr 20;83(8):1216-1236.e12. doi: 10.1016/j.molcel.2023.02.026. Epub 2023 Mar 20.PMID: 36944333 Free PMC article.
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection.
Wei J, Patil A, Collings CK, Alfajaro MM, Liang Y, Cai WL, Strine MS, Filler RB, DeWeirdt PC, Hanna RE, Menasche BL, Ökten A, Peña-Hernández MA, Klein J, McNamara A, Rosales R, McGovern BL, Luis Rodriguez M, García-Sastre A, White KM, Qin Y, Doench JG, Yan Q, Iwasaki A, Zwaka TP, Qi J, Kadoch C, Wilen CB.Nat Genet. 2023 Mar;55(3):471-483. doi: 10.1038/s41588-023-01307-z. Epub 2023 Mar 9.PMID: 36894709 Free PMC article.
BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma.
Kurata K, Samur MK, Liow P, Wen K, Yamamoto L, Liu J, Morelli E, Gulla A, Tai YT, Qi J, Hideshima T, Anderson KC.Clin Cancer Res. 2023 May 1;29(9):1807-1821. doi: 10.1158/1078-0432.CCR-22-3668.PMID: 36780189 Free PMC article.
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming.
Sevinç K, Sevinç GG, Cavga AD, Philpott M, Kelekçi S, Can H, Cribbs AP, Yıldız AB, Yılmaz A, Ayar ES, Arabacı DH, Dunford JE, Ata D, Sigua LH, Qi J, Oppermann U, Onder TT.Stem Cell Reports. 2022 Dec 13;17(12):2629-2642. doi: 10.1016/j.stemcr.2022.10.005. Epub 2022 Nov 3.PMID: 36332631 Free PMC article.
2022
BAF complex maintains glioma stem cells in pediatric H3K27M-glioma.
Panditharatna E, G Marques J, Wang T, Trissal MC, Liu I, Jiang L, Beck A, Groves A, Dharia NV, Li D, Hoffman SE, Kugener G, Shaw ML, Mire HM, Hack OA, Dempster JM, Lareau C, Dai L, Sigua LH, Quezada MA, Stanton AJ, Wyatt M, Kalani Z, Goodale A, Vazquez F, Piccioni F, Doench JG, Root DE, Anastas JN, Jones KL, Saur Conway A, Stopka S, Regan MS, Liang Y, Seo HS, Song K, Bashyal P, Jerome WP, Mathewson ND, Dhe-Paganon S, Suva ML, Carcaboso AM, Lavarino C, Mora J, Nguyen QD, Ligon KL, Shi Y, Agnihotri S, Agar NYR, Stegmaier K, Stiles CD, Monje M, Golub TR, Qi J#, Filbin MG# Cancer Discov. 2022 Oct 28:CD-21-1491. doi: 10.1158/2159-8290.CD-21-1491. Online ahead of print.PMID: 36305736
Exploring Methods of Targeting Histone Methyltransferases and Their Applications in Cancer Therapeutics.
Wang MY, Liow P, Guzman MIT, Qi J.ACS Chem Biol. 2022 Apr 1. doi: 10.1021/acschembio.2c00062. Online ahead of print.PMID: 35363464
BET-bromodomain and EZH2 inhibitor treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes.
Zaiken MC, Flynn R, Paz KG, Rhee SY, Jin S, Mohamed FA, Saha A, Thangavelu G, Park PMC, Hemming ML, Sage PT, Sharpe AH, DuPage M, Bluestone JA, Panoskaltsis-Mortari A, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Luznik L, Maillard I, Hill GR, MacDonald KP, Munn DH, Serody JS, Murphy WJ, Kean LS, Zhang Y, Bradner JE, Qi J#, Blazar BR#. Blood. 2022 Feb 28:blood.2021014557. doi: 10.1182/blood.2021014557. Online ahead of print.PMID: 35226736
EP300 selectively controls the enhancer landscape of MYCN-amplified neuroblastoma.
Durbin AD*#, Wang T*, Wimalasena VK, Zimmerman MW, Li D, Dharia NV, Mariani L, Shendy NAM, Nance S, Patel AG, Shao Y, Mundada M, Maxham L, Park PMC, Sigua LH, Morita K, Saur Conway A, Robichaud AL, Perez-Atayde AR, Bikowitz MJ, Quinn TR, Wiest OG, Easton J, Schonbrunn E, Bulyk ML, Abraham BJ, Stegmaier K#, Look AT#, Qi J.# Cancer Discovery. 2021 Nov 12:candisc.0385.2021. doi: 10.1158/2159-8290.CD-21-0385. 2022, 730-751
Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth.
Zheng S, Lin J, Pang Z, Zhang H, Wang Y, Ma L, Zhang H, Zhang X, Chen M, Zhang X, Zhao C, Qi J, Cao L, Wang M, He X, Sheng R. Adv Sci (Weinh). 2022 Aug 17:e2200750. doi: 10.1002/advs.202200750. Online ahead of print.
Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
Guan X, Cheryala N, Karim RM, Chan A, Berndt N, Qi J, Georg GI, Schönbrunn E.J Med Chem. 2022 Aug 11;65(15):10441-10458. doi: 10.1021/acs.jmedchem.2c00453. Epub 2022 Jul 22
1,4-Dihydropyridinebutyrolactone-derived ring-opened ester and amide analogs targeting BET bromodomains.
Jiang J, Zhao PL, Sigua LH, Chan A, Schönbrunn E, Qi J, Georg GI.Arch Pharm (Weinheim). 2022 Aug 8:e2200288. doi: 10.1002/ardp.202200288.
SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma.
St Pierre R, Collings CK, Samé Guerra DD, Widmer CJ, Bolonduro O, Mashtalir N, Sankar A, Liang Y, Bi WL, Gerkes EH, Ramesh V, Qi J, Smith MJ, Meredith DM, Kadoch C.Nat Genet. 2022 Jun;54(6):861-873. doi: 10.1038/s41588-022-01077-0. Epub 2022 Jun 9.PMID: 35681054
The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma.
Zullow HJ, Sankar A, Ingram DR, Samé Guerra DD, D'Avino AR, Collings CK, Lazcano R, Wang WL, Liang Y, Qi J, Lazar AJ, Kadoch C.Mol Cell. 2022 Apr 4:S1097-2765(22)00257-X. doi: 10.1016/j.molcel.2022.03.019. Online ahead of print.PMID: 35390276
A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia.
Ren Z, Kim A, Huang YT, Pi WC, Gong W, Yu X, Qi J, Jin J, Cai L, Roeder RG, Chen WY, Wang GG. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2122940119. doi: 10.1073/pnas.2122940119.PMID: 35217626
2021 Key Publications
Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma.
Ohguchi H, Park PMC, Wang T, Gryder BE, Ogiya D, Kurata K, Zhang X, Li D, Pei C, Masuda T, Johansson C, Wimalasena VK, Kim Y, Hino S, Usuki S, Kawano Y, Samur MK, Tai Y, Munshi NC, Matsuoka M, Ohtsuki S, Nakao M, Minami T, Lauberth S, Khan J, Oppermann U, Durbin AD, Anderson KC#, Hideshima T#, Qi J# (Lead Contact). Blood Cancer Discovery, In Press.
Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors.
Muthengi A,* Wimalasena VK,* Yosief HO,* Bikowitz MJ,* Sigua LH, Wang T, Li D, Gaieb Z, Dhawan G, Liu S, Erickson J, Amaro RE, Schönbrunn E#, Qi J#, Zhang W.# J Med Chem. 2021 Apr 19. doi: 10.1021/acs.jmedchem.0c02232. Online ahead of print. PMID: 33872011
2020 Key Publications
Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer.
Li F*, Ng WL*, Luster TA, Hu H, Sviderskiy VO, Dowling CM, Hollinshead KER, Zouitine P, Zhang H, Huang Q, Ranieri M, Wang W, Fang Z, Chen T, Deng J, Zhao K, So HC, Khodadadi-Jamayran A, Xu M, Karatza A, Pyon V, Li S, Pan Y, Labbe K, Almonte C, Poirier JT, Miller G, Possemato R, Qi J#, Wong KK#.
Cancer Res. 2020 Jul 9:canres.3782.2019. doi: 10.1158/0008-5472.CAN-19-3782. Online ahead of print.
Using Chemical Epigenetics to Target Cancer.
Wimalasena VK*, Wang T*, Sigua LH*, Durbin AD#, Qi J#.
Molecular Cell. 2020 May 5. pii: S1097-2765(20)30265-3. doi: 10.1016/j.molcel.2020.04.023. [Epub ahead of print] Review.
2019 Key Publications
Chemical genomics reveals histone deacetylases are required for core regulatory transcription
Berkley E. Gryder*, Lei Wu*, Girma M. Woldemichael, Silvia Pomella, Taylor R. Quinn, Paul M. C. Park, Abigail Cleveland, Benjamin Z. Stanton, Young Song, Rossella Rota, Olaf Wiest, Marielle E. Yohe, Jack F. Shern, Jun Qi‡ & Javed Khan‡.
Nature Communications. 2019 July 08; doi: 10.1038/s41467-019-11046-7
BCL2 Amplicon loss and transcriptional remodeling drives ABT-199 resistance in B-cell lymphoma models
Zhao X*, Ren Y*, Lawlor MA*, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J‡, Tao J‡.
Cancer Cell. 2019 May 13;35(5):752-766.e9. doi: 10.1016/j.ccell.2019.04.005. PMID: 31085176
Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma
Song Y*, Park PMC*, Wu L, Ray A, Picaud S, Li D, Wimalasena VK, Du T, Filippakopoulos P, Anderson KC‡, Qi J‡, Chauhan D‡.
Leukemia. 2019 April 08; doi: 10.1038/s41375-019-0467-z. PMID:30962579
2018 Key Publications
YAP1-mediated suppression of USP31 enhances NFKB activity to promote sarcomagenesis
Ye S, Lawlor MA, Rivera-Reyes A, Egolf S, Chor S, Pak K, Ciotti GE, Lee AC, Marino G, Shah J, Niedzwicki D, Weber K, Park PMC, Alam MZ, Grazioli A, Haldar M, Xu M, Perry JA, Qi J‡, Eisinger-Mathason TSK‡.
Cancer Res. 2018 May 15;78(10):2705-2720. doi: 10.1158/0008-5472.CAN-17-4052. Epub 2018 Feb 28. PMID:29490948
Leukemia-specific delivery of mutant NOTCH1 targeted therapy
Roti G*, Qi J*, Kitara S, Sanchez-Martin M, Saur Conway A, Varca AC, Su A, Wu L, Ferrando AA, Brander JE, Stegmaier K.
J Exp Med. 2018 Jan 2;215(1):197-216. doi: 10.1084/jem.20151778. Epub 2017 Nov 20. PMID:29158376
* equal contribution
‡ shared corresponding authors
Full List of Qi Lab Publications
https://www.ncbi.nlm.nih.gov/myncbi/jun.qi.1/bibliography/public/