Shane Killarney, MD, PhD

Resident, Brigham & Women's Hospital

shane

Hometown: Las Vegas, Nevada

Profiles: Google Scholar

 

Shane is an Internal Medicine resident at Brigham and Women’s Hospital. He received his B.S. in Cell and Molecular Biology from the University of Nevada, Las Vegas. Shane earned both his M.D. and Ph.D. through Duke University’s Medical Scientist Training Program (MSTP). His graduate research in Dr. Kris Wood’s laboratory focused on understanding how solid tumor populations survive first-line therapies through non-genetic resistance mechanisms.

Selected publications: 

  • Killarney, S. T.; Mesa, G.; Washart, R.; Mayro, B.; Dillon, K.; Wardell, S. E.; Newlin, M.; Lu, M.; Abu Rmaileh, A.; Liu, N.; McDonnell, D. P.; Pendergast, A. M.; Wood, K. C. PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State. Cancer Discovery 2025, 15 (3), 595–615. https://doi.org/10.1158/2159-8290.CD-24-0928.
  • Maltas, J.*; Killarney, S. T.*; Singleton, K. R.*; Strobl, M. A. R.; Washart, R.; Wood, K. C.; Wood, K. B. Drug Dependence in Cancer Is Exploitable by Optimally Constructed Treatment Holidays. Nature Ecology & Evolution 2024, 8 (1), 147–162. https://doi.org/10.1038/s41559-023-02255-x.

  • Killarney, S. T.; Washart, R.; Soderquist, R. S.; Hoj, J. P.; Lebhar, J.; Lin, K. H.; Wood, K. C. Executioner Caspases Restrict Mitochondrial RNA-Driven Type I IFN Induction during Chemotherapy-Induced Apoptosis. Nat Commun 2023, 14 (1), 1399. https://doi.org/10.1038/s41467-023-37146-z.

     

    *equal contribution