Viswanathan Lab Research

Overview

We employ both genomics and functional genetics to identify dysregulated pathways in cancer and explore how these can be targeted for therapeutic benefit.

We have several ongoing research projects in the areas outlined below with approaches ranging from genomics (dry-lab) to functional experimentation (wet-lab) to clinical/translational efforts.

Please reach out if you are interested in joining or collaborating with the lab!

Research Motivation

The genomics revolution has given us the power to understand the molecular wiring of cancer cells in unprecedented detail and has enabled the development of highly effective targeted therapies that perturb specific molecular pathways essential to the cancer cell.  Still, there are many gaps in our understanding of how cancer develops and progresses. For example:
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What are the significant drivers of cancer that occur in non-coding or “dark” regions of the genome, and how can these be rationally targeted?
What are the drivers of rare cancers that have not been comprehensively profiled?
How do cancer genomes and transcriptomes evolve during treatment?

​We are interested in exploring these and other fundamental questions in cancer biology using multidisciplinary and collaborative approaches, with the ultimate goal of laying the pre-clinical foundation for the next generation of targeted therapies that can improve outcomes for cancer patients.​