Projects
Thrombosis:
- Effect of thrombus maturation and resolvins on thrombolysis
- Inflammation and post-thrombotic syndrome
- Role of PAD4-mediated citrullination of blood components and its effect on thrombosis
Wound Healing and Angiogenesis:
- Effect of Neutrophil Extracellular Traps (NETs) and the VWF-cleaving enzyme ADAMTS13 on skin transplant and wound healing
Cancer:
- Role of PAD4 and NETs in cancer-associated venous and arterial thrombosis and systemic effects of cancer
Aging, inflammation, and organ fibrosis:
- Role of the metalloproteinase ADAMTS13
- Role of NETs and PAD4
- Role of inflammasome
Rheumatoid Arthritis:
- Establishing new models
- Role of PAD4 and inflammasome
Cell biology of NETosis:
- Role of various cellular organelles in the process
- Effects of diseases that enhance NETosis on the cellular process
- Role of NLRP3 inflammasome in NETosis
NETs in COVID-19:
- Participation in preparation of a clinical trial at Boston Children's Hospital and Brigham and Women's Hospital
- Cell biology of neutrophil activation in COVID-19